113967-50-3Relevant articles and documents
Simple Syntheses of 2-Hydroxymethyl-1,3-propanediol and Related Compounds
Latour, Stephan,Wuest, James D.
, p. 742 - 744 (2007/10/02)
A significantly improved synthesis of 2-hydroxymethyl-1,3-propanediol involves benzoylation of 2-hydroxymethyl-2-nitro-1,3-propanediol, replacement of the nitro group by hydrogen using tributylstannane, and methanolysis.Other simple procedures yield the corresponding trimethanesulfonate, triiodide, and trichloride.Dehydrohalogenation of the triiodide and the trichloride by DBU provides 3-iodo-2-(iodomethyl)propene and the corresponding dichloride, respectively.All of these useful compounds are now readily available for the first time.