114781-19-0 Usage
General Description
(S)-2-AMINO-2-ETHYLOCTANOIC ACID, also known as etilefrine, is a synthetic compound that belongs to the class of amino acid derivatives. It is a derivative of phenylephrine and is used as a sympathomimetic drug to treat hypotension and orthostatic hypotension. Etilefrine works by acting as a selective alpha-1 adrenergic receptor agonist, which causes vasoconstriction and increases blood pressure. It is used in various medical conditions, such as shock, orthostatic hypotension, and low blood pressure during anesthesia or surgery. Additionally, it is also used in the treatment of urinary incontinence and is available in both oral and injectable forms for medical use.
Check Digit Verification of cas no
The CAS Registry Mumber 114781-19-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,7,8 and 1 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 114781-19:
(8*1)+(7*1)+(6*4)+(5*7)+(4*8)+(3*1)+(2*1)+(1*9)=120
120 % 10 = 0
So 114781-19-0 is a valid CAS Registry Number.
114781-19-0Relevant articles and documents
Chemo-Enzymic Synthesis of Optically Active α,α-Disubstituted α-Amino Acids
Liu, Weiguo,Ray, Paul,Benezra, Steven A.
, p. 553 - 560 (2007/10/02)
A series of α,α-disubstituted α-amino esters was chemically synthesized and then resolved through enantioselective hydrolysis catalysed by a new enzyme isolated from crude Humicola langinosa lipase.This enzyme only accepts free amino esters as substrates with neither lipase activity toward olive oil nor esterase activity toward o-nitrophenyl butyrate.It is unique in that it successfully catalyses the resolution of amino esters with two large α-alkyl groups including aliphatic, aromatic and cyclic amino esters.Examples of resolutions where the alkyl groups differ in size by as little as a single carbon atom have been demonstrated.For determination of absolute configuration, some of the optically active α,α-disubstituted amino acids were also prepared through Schoellkopf's asymmetric synthesis and the structures were verified by X-ray crystallography.A model depicting the substrate binding site of the enzyme is proposed.
