114991-54-7Relevant articles and documents
NUOVI DERIVATI DI 7-AMMINO-2,3-POLIMETILENINDOLI AD ATTIVITA ANTIINFIAMMATORIA
Cerri, R.,Pau, A.,Boatto, G.,Sparatore, F.,Satta, M.,Capasso, F.
, p. 91 - 102 (2007/10/02)
Thirthyfour new N-acylderivatives of 7-amino-2,3-polymethyleneindoles (I) and (II) were prepared and tested, together with a few analogues previously obtained, against carrageenan edema in the rat.Several compounds, at a dose of 1 mmole/kg, exhibit good inhibitory activity, that in some cases is superior to that displayed by indomethacin at a dose of 5 mg/kg.With only one exception, activity is confined to compounds of formula (I) and, generally, derivatives of 2,3-hexamethyleneindole are more active than those of lower homologues.