Welcome to LookChem.com Sign In|Join Free

CAS

  • or

115103-85-0

115103-85-0

Post Buying Request

115103-85-0 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

  • Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(diMethylaMino)-3-oxopropyl]thio]Methyl]thio]-, sodiuM salt, (E)-

    Cas No: 115103-85-0

  • No Data

  • No Data

  • No Data

  • Antimex Chemical Limied
  • Contact Supplier

  • Propanoic acid, 3-[[[3-[2-(7-chloro-2-quinolinyl)ethenyl]phenyl][[3-(diMethylaMino)-3-oxopropyl]thio]Methyl]thio]-, sodiuM salt, (E)-

    Cas No: 115103-85-0

  • No Data

  • No Data

  • No Data

  • LEAP CHEM Co., Ltd.
  • Contact Supplier

115103-85-0 Usage

Uses

MK-571 sodium salt hydrate has been used:as an efflux inhibitor for monitoring multidrug resistance protein (MRP)-function and to avoid redundancy of other transportersto assess its effect on cell proliferation and 2D-migration in vitro in various cell lines of glioblastoma multiforme (GBM)as multidrug resistance (MDR) transporter inhibitor to study its effects in ovarian cancer cellsas specific inhibitors of ABCC1/2 to investigate transport, toxicity, flow cytometry and arsenic efflux

Biological Activity

mk571 sodium salt is a specific cyslt1 (cysteinyl-leukotriene type 1 receptor) antagonist [1].cysteinyl leukotriene receptor 1, also termed as cysltr1, is a receptor for cysteinyl leukotrienes (lt)which mediates a large variety of allergic and hypersensitivity reactions in humans [2].

Biochem/physiol Actions

MK 571 is a potent and selective leukotriene D4 (LTD4) antagonist and ABCC multidrug resistance protein 1(MRP1) inhibitor. The cysteinyl leukotrienes (CysLTs), LTC4, LTD4, and LTE4, mediate their actions through two distinct G-protein coupled receptors. LTD4 is the preferred ligand for the CysLT1 receptor, whereas LTC4 and LTD4 bind with approximately equal affinity to the CysLT2 receptor. MK 571 is a selective, orally active CysLT1 receptor antagonist. It blocks the binding of LTD4, but not LTC4, to human and guinea pig lung membranes with Ki values of 0.22 nM and 2.1 nM, respectively. MK 571 effectively blocks LTD4 activation of recombinant human and mouse CysLT1 receptors but is ineffective at blocking LTC4 or LTD4 activation of the recombinant human or murine CysLT2 receptors. It potentially inhibits MRP1 and has been shown to overcome acquired arsenic tolerance.

in vitro

mk571 is a multidrug resistance protein-2 (abcc2, mrp2) inhibitor and had been widely used to demonstrate the role of mrp2 in the cellular efflux of drugs, xenobiotics and their conjugates. apically-applied mk571 resulted in significant reductions in both the apical and basolateral efflux of flavonol conjugates from caco-2/tc7 monolayers. the estimated ki for inhibition of the synthesis of k-4′-o-glca by mk571 is 19.7 μm. mk571 inhibited the intracellular biosynthesis of all flavonol glucuronides and sulphates by caco-2 cells in a dose-dependent manner. mk571 significantly inhibited phase-2 conjugation of kaempferol by cell-free extracts of caco-2, and competitively inhibited the production of kaempferol-4′-o-glucuronide. these data indicated that mk571, in addition to inhibiting mrp2, was a potential inhibitor of enterocyte phase-2 conjugation [3].

references

[1]. thivierge m, turcotte s, rola-pleszczynski m, et al. enhanced cysteinyl-leukotriene type 1 receptor expression in t cells from house dust mite-allergic individuals following stimulation with der p[j]. journal of immunology research, 2015, 2015.[2]. singh rk, tandon r, dastidar sg, ray a (november 2013). "a review on leukotrienes and their receptors with reference to asthma". the journal of asthma. 50 (9): 922–31.[3]. barrington r d, needs p w, williamson g, et al. mk571 inhibits phase-2 conjugation of flavonols by caco-2/tc7 cells, but does not specifically inhibit their apical efflux[j]. biochemical pharmacology, 2015, 95(3): 193-200.

Check Digit Verification of cas no

The CAS Registry Mumber 115103-85-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,1,0 and 3 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 115103-85:
(8*1)+(7*1)+(6*5)+(5*1)+(4*0)+(3*3)+(2*8)+(1*5)=80
80 % 10 = 0
So 115103-85-0 is a valid CAS Registry Number.

115103-85-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail

  • Sigma

  • (M7571)  MK-571 sodium salt hydrate  ≥95% (HPLC)

  • 115103-85-0

  • M7571-5MG

  • 1,224.99CNY

  • Detail

  • Sigma

  • (M7571)  MK-571 sodium salt hydrate  ≥95% (HPLC)

  • 115103-85-0

  • M7571-25MG

  • 4,885.92CNY

  • Detail

115103-85-0Upstream product

115103-85-0Downstream Products

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 115103-85-0