115104-25-1Relevant articles and documents
Novel N-acylated heterocycles
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, (2008/06/13)
Described are compositions comprising a muscarinic receptor antagonist and an N-acylated heterocycle derivative having affinity for serotonergic receptors, and enantiomers, diastereoisomers, N-oxides, polymorphs, solvates and pharmaceutically acceptable salts thereof. The combination of a muscarinic receptor antagonist and an N-acylated heterocycle, or an enantiomer, diastereoisomer, N-oxide, polymorph, solvate or pharmaceutically acceptable salt thereof, is useful in the treatment of patients with neuromuscular dysfunction of the lower urinary tract and diseases related to 5-HT1A receptors.
Synthesis and SAR of a novel, potent and structurally simple LTD4 antagonist of the quinoline class
Von Sprecher, Andreas,Gerspacher, Marc,Beck, Andreas,Kimmel, Sabine,Wiestner, Hansruedi,Anderson, Gary P.,Niederhauser, Ulrich,Subramanian, Natarajan,Bray, Michael A.
, p. 965 - 970 (2007/10/03)
The two geminal ethyl groups in the succinic acid moiety of CGP57698 (4- [3-(7-fluoro-2-quinolinylmethoxy)phenyl-amino]-2,2-diethyl-4-oxo-butanoic acid) are responsible for the high in vitro and in vivo potency of this peptidoleukotriene antagonist of the quinoline type. The synthesis and structure activity relationships of CGP57698 and its analogs are described.
2-ANILINO PHENYLACETIC ACID DERIVATIVES
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, (2008/06/13)
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