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1156-99-6

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1156-99-6 Usage

General Description

10-hydroxynortriptyline is a metabolite of the tricyclic antidepressant medication nortriptyline. It is formed in the body when nortriptyline is metabolized by the CYP2D6 enzyme. 10-hydroxynortriptyline has been found to have similar pharmacological activity to nortriptyline, and is also thought to contribute to the therapeutic effects of the medication. It has been shown to have antidepressant and analgesic properties, and is also associated with side effects such as drowsiness, dry mouth, and constipation. Studies have shown that the levels of 10-hydroxynortriptyline in the body can vary widely between individuals, and these differences may impact the effectiveness and side effects of nortriptyline treatment.

Check Digit Verification of cas no

The CAS Registry Mumber 1156-99-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,5 and 6 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1156-99:
(6*1)+(5*1)+(4*5)+(3*6)+(2*9)+(1*9)=76
76 % 10 = 6
So 1156-99-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H21NO.C4H4O4/c1-20-12-6-11-16-15-8-3-2-7-14(15)13-19(21)18-10-5-4-9-17(16)18;5-3(6)1-2-4(7)8/h2-5,7-11,19-21H,6,12-13H2,1H3;1-2H,(H,5,6)(H,7,8)/b16-11+;2-1-

1156-99-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 10-Hydroxynortriptyline

1.2 Other means of identification

Product number -
Other names 5-[3-Methylamino-prop-(Z)-ylidene]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-10-ol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1156-99-6 SDS

1156-99-6Downstream Products

1156-99-6Relevant articles and documents

Drug Oxidation by Cytochrome P450BM3: Metabolite Synthesis and Discovering New P450 Reaction Types

Ren, Xinkun,Yorke, Jake A.,Taylor, Emily,Zhang, Ting,Zhou, Weihong,Wong, Luet Lok

, p. 15039 - 15047 (2015)

There is intense interest in late-stage catalytic C-H bond functionalization as an integral part of synthesis. Effective catalysts must have a broad substrate range and tolerate diverse functional groups. Drug molecules provide a good test of these attributes of a catalyst. A library of P450BM3 mutants developed from four base mutants with high activity for hydrocarbon oxidation produced human metabolites of a panel of drugs that included neutral (chlorzoxazone, testosterone), cationic (amitriptyline, lidocaine) and anionic (diclofenac, naproxen) compounds. No single mutant was active for all the tested drugs but multiple variants in the library showed high activity with each compound. The high conversions enabled full product characterization that led to the discovery of the new P450 reaction type of oxidative decarboxylation of an α-hydroxy carboxylic acid and the formation a protected imine from an amine, offering a novel route to α-functionalization of amines. The substrate range and varied product profiles suggest that this library of enzymes is a good basis for developing late-stage C-H activation catalysts.

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