115869-19-7Relevant articles and documents
AN IMPROVED SYNTHESIS OF 1-ALKYL-4-IMIDAZOLIN-2-ONES
Wong, Ooi,Tsuzuki, Noriko,Richardson, Mark,Rytting, Howard,Konishi, Ryoji,Higuchi, Takeru
, p. 3153 - 3158 (1987)
Two 1-alkyl-4-imidazolin-2-ones were prepared by acid-catalysed cyclization of N-(2,2-dialkoxyethyl)-N-alkylureas with improved yields of over 90 percent.The amount of HCl used in the reaction and the proper isolation procedure are the important factors in obtaining the high yields.
2-ARYLTHIAZOLE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS
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Page/Page column 38, (2010/11/28)
The invention encompasses compounds of Formula I or pharmaceutically acceptable salts thereof, which are modulators of the CXCR3 chemokine receptor function useful for the treatment or prevention of pathogenic inflammatory processes, autoimmune diseases or graft rejection processes. Methods of use and pharmaceutical compositions are also encompassed.