115899-40-6Relevant articles and documents
Synthesis and enzymatic incorporation of modified deoxyuridine triphosphates
Borsenberger, Vinciane,Kukwikila, Mikiembo,Howorka, Stefan
, p. 3826 - 3835 (2009)
We describe the synthesis of 2′-deoxyuridine-5′-triphosphate derivatives bearing linkers of varying length, bulk and flexibility, at position 5 of the pyrimidine base. Nucleotide analogues with terminal functional groups are of interest due to their appli
MODIFIED NUCLEOTIDES AND USES THEREOF
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Paragraph 0404, (2021/10/30)
Disclosed herein, inter alia, are compounds, modified nucleotides, compositions, and methods of using the same.
NUCLEOTIDE CLEAVABLE LINKERS AND USES THEREOF
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Paragraph 0778, (2020/07/26)
Disclosed herein, inter alia, are compounds, compositions, and methods of use thereof for sequencing a nucleic acid.
DISULFIDE-LINKED REVERSIBLE TERMINATORS
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Paragraph 00123, (2016/11/28)
The present disclosure provides methods of sequencing polynucleotides and compounds, compositions useful for sequencing of polynucleotides. The chemical compounds include nucleotides and their analogs which possess a sugar moiety comprising a cleavable chemical group capping the 3'-OH group and a base that is attached to a detectable label through a cleavable linker comprising a disulfide bond. In addition, both the disulfide bond and the cleavable chemical group are cleavable by a chemical reagent. Furthermore, after the disulfide bond is cleaved by the chemical reagent, there is no free thiol group linked to the base of the nucleotides.
