117632-48-1Relevant articles and documents
STEREOSELECTIVE SYNTHESES OF 2-SUBSTITUTED PERHYDROFUROFURANS
Vader, Jan,Koopmans, Rimco,Groot, Aede De,Veldhuizen, Albertus van,Kerk, Sies van der
, p. 2663 - 2674 (2007/10/02)
New reagents for the stereoselective synthesis of 2-substituted perhydrofurofurans are described.In the successful approach towards the latter compounds, the key steps were the addition of a monolithio-2α-methoxy-3β-perhydrofuran to an aldehyde and a dilithio-2α-methoxy-3β-perhydrofuran to a carboxyl derivative, respectively.The structures and conformations of the 2-tert-butyl- and 2-isopropylperhydrofurofurans were examined by means of (1)H-NMR double resonance and the 2D-NOE spectroscopy.