118354-71-5Relevant articles and documents
Development of a Dual-Acting Antibacterial Agent (TNP-2092) for the Treatment of Persistent Bacterial Infections
Ma, Zhenkun,Lynch, Anthony Simon
, p. 6645 - 6657 (2016/08/05)
The clinical management of prosthetic joint infections and other persistent bacterial infections represents a major unmet medical need. The rifamycins are one of the most potent antibiotic classes against persistent bacterial infections, but bacteria can
METHOD FOR PRODUCTION OF OPTICALLY ACTIVE 3-AMINO-NITROGENATED COMPOUND
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Page/Page column 18, (2009/05/29)
Aiming at production of an optically active 3-amino nitrogen-containing compound which is useful as an intermediate in synthesis of medicines and pesticides, in particular, an optically active 1-protected-3-aminopyrrolidine derivative, from an inexpensive and readily available raw material by a process which is efficient and can be practiced industrially, an optically active 3-amino nitrogen-containing compound is produced by performing a reaction of an optically active 3-substituted nitrogen-containing compound with ammonia, methylamine, ethylamine or dimethylamine in the presence of water. In addition, a 1-protected-3-aminopyrrolidine derivative is produced by performing a reaction of an optically active 1-protected-3-(sulfonyloxy)pyrrolidine derivative with ammonia, methylamine, ethylamine, or dimethylamine in the presence of methanol, ethanol, n-propanol, or isopropanol under a pressure of less than 30 barr.
Synthesis of beta-proline like derivatives and their evaluation as sodium channel blockers
Muraglia, Marilena,Franchini, Carlo,Corbo, Filomena,Scilimati, Antonio,Sinicropi, Maria Stefania,De Luca, Annamaria,De Bellis, Michela,Camerino, Diana Conte,Tortorella, Vincenzo
, p. 1099 - 1103 (2008/09/17)
(Chemical Equation Presented) A simple and convenient procedure for the preparation of beta-proline like derivatives in their racemic and optically active forms has been reported. The compounds have been screened for their potential activity as sodium cha