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118399-22-7

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  • Cyclo[(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-4,6-decadienoyl-D-g-glutamyl-(2Z)-2-(methylamino)-2-butenoyl-(3S)-3-methyl-D-b-aspartyl-L-arginyl]

    Cas No: 118399-22-7

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118399-22-7 Usage

Description

The cyanobacterium Nodularia spumigena often contaminates the drinking water of rural communities in developing countries and accumulates in mussels, flounder, and cod from the northern Baltic Sea. Nodularin is a hepatotoxic monocylic pentapeptide produced by the N. spumigena. It is a potent inhibitor of protein phosphatase types 1 (PP1) and 2A (PP2A), exhibiting IC50 values of 1.8 and 0.026 nM, respectively. PP2B is inhibited to a lesser extent with an IC50 of 1.8 μM. No apparent inhibitory effect is observed with PP2C, alkaline phosphatase, acid phosphatase, insulin receptor tyrosine kinase, protein kinase A, phosphorylase kinase, or protein kinase C.

Uses

Nodularin-R is a cyclic peptide toxin produced by freshwater cyanobacteria.

Check Digit Verification of cas no

The CAS Registry Mumber 118399-22-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,3,9 and 9 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 118399-22:
(8*1)+(7*1)+(6*8)+(5*3)+(4*9)+(3*9)+(2*2)+(1*2)=147
147 % 10 = 7
So 118399-22-7 is a valid CAS Registry Number.
InChI:InChI=1/C41H60N8O10/c1-8-31-38(54)48-34(40(57)58)26(5)36(52)46-29(15-12-20-44-41(42)43)37(53)45-28(25(4)35(51)47-30(39(55)56)18-19-33(50)49(31)6)17-16-23(2)21-24(3)32(59-7)22-27-13-10-9-11-14-27/h8-11,13-14,16-17,21,24-26,28-30,32,34H,12,15,18-20,22H2,1-7H3,(H,45,53)(H,46,52)(H,47,51)(H,48,54)(H,55,56)(H,57,58)(H4,42,43,44)/b17-16+,23-21+,31-8+

118399-22-7 Well-known Company Product Price

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  • Sigma-Aldrich

  • (32539)  Nodularinsolution  10 μg/mL in methanol, analytical standard

  • 118399-22-7

  • 32539-1ML

  • 3,791.97CNY

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118399-22-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (2Z,5R,6S,9S,12S,13S,16R)-9-[3-(diaminomethylideneamino)propyl]-2-ethylidene-12-[(1E,3E,5S,6S)-6-methoxy-3,5-dimethyl-7-phenylhepta-1,3-dienyl]-1,6,13-trimethyl-3,7,10,14,19-pentaoxo-1,4,8,11,15-pentazacyclononadecane-5,16-dicarboxylic acid

1.2 Other means of identification

Product number -
Other names Nodularin solution

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:118399-22-7 SDS

118399-22-7Relevant articles and documents

Acyloxymethyl esterification of nodularin-R and microcystin-LA produces inactive protoxins that become reactivated and produce apoptosis inside intact cells

Herfindal, Lars,Kasprzykowski, Franciszek,Schwede, Frank,?ankiewicz, Leszek,Fladmark, Kari E.,?ukomska, Joanna,Wahlsten, Matti,Sivonen, Kaarina,Grzonka, Zbigniew,Jastorff, Bernd,D?skeland, Stein Ove

body text, p. 5759 - 5762 (2010/03/24)

We report the esterification of the carboxyl groups of the cyclic peptide toxins nodularin-R and microcystin-LA to produce stable diacetoxymethyl and dipropionyloxymethyl ester derivatives. The derivatives had no activity but were reactivated upon esteras

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