118486-95-6Relevant articles and documents
Adenosine receptor antagonists
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Paragraph 0117-0120, (2020/12/15)
The invention provides a compound shown as a formula (I) and a pharmaceutical composition thereof. The compounds of formula (I) of the present invention are useful as adenosine receptor inhibitors, especially A2A and/or A2B inhibitors, for example, the product can be used for prevention or treatment of diseases associated with A2A and/or A2B activity or expression.
P2X3 AND/OR P2X2/3 COMPOUNDS AND METHODS
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Paragraph 0231; 0232, (2015/07/07)
The present application provides novel compounds and methods for preparing and using these compounds. In one embodiment, the compounds are of the structure of formula (I), wherein R1-R4 are defined herein. In a further embodiment, these compounds are useful in method for regulating one or both of the P2X3 or P2X2/3 receptors. In another embodiment, these compounds are useful for treating pain in patients by administering one or more of the compounds to a patient.
Oxidative Substitution Reactions of Organostannyl Compounds with Lead Tetraacetate. A Convenient Route to 5-Alkylidene-2(5H)-furanones
Yamamoto, Makoto,Munakata, Hiroshi,Kishikawa, Keiki,Kohmoto, Shigeo,Yamada, Kazutoshi
, p. 2366 - 2370 (2007/10/02)
5-Substituted 2-tributylstannylfurans which were synthesized by the reaction of corresponding 5-substituted 2-lithiofurans with tribitylstannyl chloride, were treated with two equimolar amounts of lead tetraacetate at room temperature to give corresponding 5-substituted 5-acetoxy-2(5H)-furanones in good yields.The 5-acetoxy-2(5H)-furanone was heated at 80 deg C in acetic acid-acetic anhydride containing a catalytic amount of concentrated sulfuric acid to give 5-alkylidene-2(5H)-furanone in moderate yield.
