118553-21-2Relevant articles and documents
Catalytic Dehydrogenative β-Alkylation of Amino Acid Schiff Bases with Hydrocarbon
Ikeda, Tetsu,Ochiishi, Haruka,Yoshida, Mana,Yazaki, Ryo,Ohshima, Takashi
, p. 369 - 373 (2022/01/04)
A synthetic method for the synthesis of a highly congested α,β-dehydroamino acid through the β-C–H bond activation of an amino acid Schiff base is described. Abundant hydrocarbon feedstock could be used as an alkylating reagent to afford an α,β-dehydroamino acid bearing a quaternary carbon at the γ-position with an exclusively (Z)-geometry. Notably, a tetrasubstituted olefin could be constructed from saturated starting materials. The transformation of the synthesized α,β-dehydroamino acid into unnatural α-amino acid derivatives was also demonstrated.
Alkyl 2-(Diphenylmethyleneamino)acrylates in the Synthesis of α-Amino Acids
Tarzia, Giorgio,Balsamini, Cesarino,Spadoni, Gilberto,Duranti, Ermanno
, p. 514 - 517 (2007/10/02)
Stable alkyl 2-(diphenylmethyleneamino)acrylates, readily prepared from glycine, are useful synthons for the synthesis of racemic 3-substituted alkyl alaninates via Michael type and Lewis acid catalyzed additions.
