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1193-64-2

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1193-64-2 Usage

Uses

Pyromeconic Acid O-Methyl Ether is used in the synthesis of the derivative (Arecolidine) of Arecoline (A767500), a cholinergic alkaloid from seeds of the betel nut palm Areca catechu. Anthelmintic (Cestodes); cathartic.

Check Digit Verification of cas no

The CAS Registry Mumber 1193-64-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,9 and 3 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1193-64:
(6*1)+(5*1)+(4*9)+(3*3)+(2*6)+(1*4)=72
72 % 10 = 2
So 1193-64-2 is a valid CAS Registry Number.

1193-64-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-O-methyl pyromeconate

1.2 Other means of identification

Product number -
Other names Pyromeconic Acid O-Methyl Ether

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1193-64-2 SDS

1193-64-2Relevant articles and documents

-

Bickel

, p. 1801 (1947)

-

Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity

Bai, Renren,Gu, Jinping,Guo, Jianan,Jiang, Xiaoying,Lv, Yangjing,Mi, Zhisheng,Shi, Yuan,Xie, Yuanyuan,Yao, Chuansheng,Zhang, Changjun,Zhou, Tao

, (2020/05/22)

A series of (3-hydroxypyridin-4-one)-coumarin hybrids were developed and investigated as potential multitargeting candidates for the treatment of Alzheimer's disease (AD) through the incorporation of iron-chelating and monoamine oxidase B (MAO-B) inhibition. This combination endowed the hybrids with good capacity to inhibit MAO-B as well as excellent iron-chelating effects. The pFe3+ values of the compounds were ranging from 16.91 to 20.16, comparable to more potent than the reference drug deferiprone (DFP). Among them, compound 18d exhibited the most promising activity against MAO-B, with an IC50 value of 87.9 nM. Moreover, compound 18d exerted favorable antioxidant activity, significantly reversed the amyloid-β1-42 (Aβ1-42) induced PC12 cell damage. More importantly, 18d remarkably ameliorated the cognitive dysfunction in a scopolamine-induced mice AD model. In brief, a series of hybrids with potential anti-AD effect were successfully obtained, indicating that the design of iron chelators with MAO-B inhibitory and antioxidant activities is an attractive strategy against AD progression.

STUDIES TOWARDS 3,4-DIMETHOXY-1-METHYL-1,2-DIHYDROPYRIDINE, SO CALLED ARECOLIDINE, OR ITS TAUTOMERS

Dehmlow, Eckehard V.,Westerheide, Ralf

, p. 355 - 366 (2007/10/02)

Different synthetic paths towards the title compound (2) lead to intermediates (3, 11, 13, 14, 15, and 17).All of these, but especially 3 and 14 are very close to the target molecule or its tautomers.These, however, turn out to be too unstable for isolation.Thus, the structure of the compound described as arecolidine must be wrong.

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