119322-88-2Relevant articles and documents
A new chiral sulfonamide ligand based on tartaric acid: synthesis and application in the enantioselective addition of diethylzinc to aldehydes and ketones
Hui, Ailing,Zhang, Jintang,Fan, Jinmin,Wang, Zhiyong
, p. 2101 - 2107 (2006)
A new sulfonamide ligand based on l-tartaric acid was synthesized and was employed as a chiral ligand in the enantioselective addition of diethylzinc to aldehydes, giving rise to the best enantiomeric excess up to 83% with 5 mol % of catalyst loading. Moreover, the addition of diethylzinc to ketones can also be achieved with good to excellent enantioselectivities by employing 7 mol % of the catalyst under mild conditions.
Two new phenolic amides from the seeds of Pharbitis nil
Kim, Ki Hyun,Choi, Sang Un,Son, Mi Won,Lee, Kang Ro
, p. 1532 - 1535 (2010)
Two new phenolic amides, pharnilatins A (1) and B (2), were isolated from the seeds of Pharbitis nil. These new compounds possess a p-coumaroyl unit with a structurally unique side chain, (2S,3S)-2,3-dihydroxyputrescine. The chemical structures and absolute stereochemistries of the new compounds were determined on the basis of spectroscopic analyses including 1D- and 2D-NMR experiments and chemical reactions. Compounds 1 and 2 exhibited cytotoxicity against A549, SK-OV-3, SK-MEL-2, and HCT-15 human tumor cells. However, none of the compounds inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated microglia cells.
The Detosylation of Chiral 1,2-Bis(tosylamides)
Gaston, Jayden J.,Tague, Andrew J.,Smyth, Jamie E.,Butler, Nicholas M.,Willis, Anthony C.,van Eikema Hommes, Nico,Yu, Haibo,Clark, Timothy,Keller, Paul A.
, p. 9163 - 9180 (2021/07/19)
The deprotection of chiral 1,2-bis(tosylamides) to their corresponding 1,2-diamines is mostly unsuccessful under standard conditions. In a new methodology, the use of Mg/MeOH with sufficient steric additions allows the facile synthesis of 1,2-diamines in 78-98% yields. These results are rationalized using density functional theory and the examination of inner and outer-sphere reduction mechanisms.
