119992-99-3Relevant articles and documents
Improved manidipine dihydrochloride II crystal form production method
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Paragraph 0046; 0047, (2018/07/30)
The invention discloses an improved manidipine dihydrochloride II crystal form production method. The method comprises the steps: adding concentrated grease containing manidipine alkali into ethyl alcohol, stirring to befor crystallizedcrystallizing, filtering to obtain filter cake and pulping and washing to obtain the manidipine alkali; then utilizing hydrochloric acid salification to obtain a manidipine dihydrochloride crude product; heating and dissolving the manidipine dihydrochloride crude product by methyl alcohol containing water, performing thermal-insulation filtration, crystallization and filtration, collecting separated-out crystal and drying to obtain the manidipine dihydrochloride II crystal form. The purity of the II crystal form obtained by the production method disclosed bythe invention is larger than 99.8%, and the method has very great guiding significance in researches of the manidipine dihydrochloride crystal form and clinical application of manidipine dihydrochloride.
S-Manidipine hydrochloride crystal form I and preparation method thereof
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Paragraph 0054; 0055, (2017/04/08)
The invention relates to an S-Manidipine hydrochloride crystal form I and a preparation method thereof. The preparation method includes: dissolving S-Manidipine free alkali into alcohols or alcohol/water, salifying with HCL, and crystallizing to obtain S-Manidipine hydrochloride crystal which is determined as the crystal form I according to X-ray powder diffraction detection. Products of the S-Manidipine hydrochloride crystal form I have excellent temperature and humidity stability, meet quality requirements on residual solvent and moisture and are suitable for preparation process and long-term storage. Pharmaceutical compositions with compounds of the crystal form I serving as active ingredients can be used for treating diseases such as hypertension and the like.
POLYMORPHIC FORMS OF MANIDIPINE
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, (2011/04/14)
The invention relates to various new polymorphic forms of manidipine and pharmaceutically acceptable salts thereof. The invention also relates to processes for the preparation of the polymorphic forms of manidipine and pharmaceutically acceptable salts thereof.
