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1204-68-8

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1204-68-8 Usage

General Description

N,N-Bis(2-chloroethyl)-4-methylaniline, also known as mechlorethamine, is a nitrogen mustard compound that has been used as a chemotherapeutic agent in the treatment of various types of cancer, including Hodgkin’s disease, non-Hodgkin’s lymphoma, and leukemia. It works by alkylating DNA, which ultimately leads to cellular death. Mechlorethamine is a highly reactive and toxic compound and can cause severe damage to tissues and organs if not handled properly. Due to its toxic nature, it is classified as a hazardous substance, and strict safety precautions must be taken when handling and using this chemical. Despite its toxicity, mechlorethamine has been an important drug in the treatment of certain types of cancer and continues to be used in medical settings.

Check Digit Verification of cas no

The CAS Registry Mumber 1204-68-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,0 and 4 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1204-68:
(6*1)+(5*2)+(4*0)+(3*4)+(2*6)+(1*8)=48
48 % 10 = 8
So 1204-68-8 is a valid CAS Registry Number.
InChI:InChI=1/C11H15Cl2N/c1-10-2-4-11(5-3-10)14(8-6-12)9-7-13/h2-5H,6-9H2,1H3

1204-68-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name N,N-bis(2-chloroethyl)-4-methylaniline

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1204-68-8 SDS

1204-68-8Relevant articles and documents

Hypoxia-Selective Antitumor Agents. 3. Relationships between Structure and Cytotoxicity against Cultured Tumor Cells for Substituted N,N-Bis(2-chloroethyl)anilines

Palmer, Brian D.,Wilson, William R.,Pullen, Susan M.,Denny, William A.

, p. 112 - 121 (2007/10/02)

A series of aniline mustards with a wide range of electron-donating and -withdrawing substituents in the 3- and 4-positions has been synthesized and evaluated for cytotoxicity in cell culture to examine the potential of using nitro group deactivated nitrogen mustards for the design of novel hypoxia-selective anticancer drugs (Denny, W.A.; Wilson, W.R.J.Med Chem. 1986, 29, 879).Hydrolytic half-lives in tissue culture media, determined by bioassay against a cell line (UV4) defective in the repair of DNA interstrand cross-links showed the expected dependence on the Hammett electronic parameter, ?, varying from 0.13 h for the 4-amino analogue to >100 h for analogues with strongly electron-withdrawing substituents.Cytotoxic potencies in aerobic UV4 cultures showed a similar dependence on ?.This dependence predicted that the 4-nitroaniline mustard would be 7200-fold less potent than its potential six-electron reduction product, the 4-amino compound, in growth inhibition assays using a 1-h drug exposure.The measured differential was much lower (225-fold) because of the instability of the latter compound, but a differential of 17500-fold was observed in the initial rate of killing by using a clonogenic assay.The potential for formation of reactive mustards by reduction to the amine or hydroxylamine was demonstrated by the 4-nitroso compound, which had an aerobic toxicity similar to that of the amine.Although these features confirmed the original rationale, the 3-nitro- and 4-nitroaniline mustards had only minimal hypoxic selectivity against UV cells.Toxicity to hypoxic cells appears to be limited by the low reduction potentials of these compounds and consequent lack of enzymatic nitroreduction.However, this study has demonstrated that nitro groups can be used to latentiate aromatic nitrogen mustards and indicates that examples with higher reduction potentials could provide useful hypoxia-selective therapeutic agents.

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