120546-67-0 Usage
Description
Thiazolo[4,5-h]isoquinoline, 6,7,8,9-tetrahydro(9CI) is a series of 7,8-fused heterocyclic tetrahydroisoquinolines, which are complex organic compounds with a unique chemical structure. These compounds have been synthesized and characterized for their potential applications in various fields.
Uses
Used in Pharmaceutical Industry:
Thiazolo[4,5-h]isoquinoline, 6,7,8,9-tetrahydro(9CI) is used as an inhibitor for rabbit adrenal phenylethanolamine-N-methyltransferase (PNMT). This application is significant because PNMT is an enzyme involved in the biosynthesis of catecholamines, which are neurotransmitters and hormones that play a crucial role in various physiological processes, including stress response, mood regulation, and alertness. By inhibiting PNMT, these compounds can potentially be used to modulate the levels of catecholamines in the body, which may have therapeutic implications for conditions related to catecholamine imbalances.
Please note that the provided materials do not mention any other specific applications or industries for Thiazolo[4,5-h]isoquinoline, 6,7,8,9-tetrahydro(9CI). The information given is limited to its use as an inhibitor of PNMT in the pharmaceutical industry.
Check Digit Verification of cas no
The CAS Registry Mumber 120546-67-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,0,5,4 and 6 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 120546-67:
(8*1)+(7*2)+(6*0)+(5*5)+(4*4)+(3*6)+(2*6)+(1*7)=100
100 % 10 = 0
So 120546-67-0 is a valid CAS Registry Number.
120546-67-0Relevant articles and documents
Tetrahydrothiadiazoloisoquinolines: Synthesis and inhibition of phenylethanolamine-N-methyltransferase
Girard,Bondinell,Hillegass,Holden,Pendleton,Uzinskas
, p. 1566 - 1571 (2007/10/02)
A series of 7,8-fused heterocyclic tetrahydroisoquinolines were synthesized and tested as inhibitors of rabbit adrenal phenylethanolamine-N-methyltransferase (PNMT). 6,7,8,9-Tetrahydro[1,2,3]thiadiazolo[5,4-h]isoquinoline 5 (SK and F 86607) was found to b
