121168-73-8Relevant articles and documents
Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: A new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models
Cowart, Marlon D.,Altenbach, Robert J.,Liu, Huaqing,Hsieh, Gin C.,Drizin, Irene,Milicic, Ivan,Miller, Thomas R.,Witte, David G.,Wishart, Neil,Fix-Stenzel, Shannon R.,McPherson, Michael J.,Adair, Ronald M.,Wetter, Jill M.,Bettencourt, Brian M.,Marsh, Kennan C.,Sullivan, James P.,Honore, Prisca,Esbenshade, Timothy A.,Brioni, Jorge D.
experimental part, p. 6547 - 6557 (2009/10/09)
A new structural class of histamine H4 receptor antagonists (6-14) was designed based on rotationally restricted 2,4-diaminopyrimidines. Series compounds showed potent and selective in vitro H4 antagonism across multiple species, goo