121524-09-2 Usage
Biochem/physiol Actions
SR58611A is a potent, specific b3 adrenergic receptor agonist. The EC50 for reduction of β3-mediated spontaneous motility in rat distal colon sections is 3.5 nM. Minimal anti-depressant efficacious doses for SR58611A are 0.1-0.3 mpk in rodent models.
Check Digit Verification of cas no
The CAS Registry Mumber 121524-09-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,1,5,2 and 4 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 121524-09:
(8*1)+(7*2)+(6*1)+(5*5)+(4*2)+(3*4)+(2*0)+(1*9)=82
82 % 10 = 2
So 121524-09-2 is a valid CAS Registry Number.
InChI:InChI=1/C22H26ClNO4.ClH/c1-2-27-22(26)14-28-20-9-7-15-6-8-19(11-17(15)12-20)24-13-21(25)16-4-3-5-18(23)10-16;/h3-5,7,9-10,12,19,21,24-25H,2,6,8,11,13-14H2,1H3;1H/t19-,21-;/m0./s1
121524-09-2Relevant articles and documents
Alternative synthesis of the chiral atypical β-adrenergic phenylethanolaminotetraline agonist SR58611A using enantioselective hydrogenation
Devocelle, Marc,Mortreux, Andre,Agbossou, Francine,Dormoy, Jean-Robert
, p. 4551 - 4554 (1999)
We have developed an alternative synthesis of the atypical β-adrenergic phenylethanolaminotetraline agonist SR58611A. Two key intermediates have been synthesised involving enantioselective hydrogenation of an aminoketone and an enamide providing the corre
