121705-84-8Relevant articles and documents
Synthesis and Biological Studies of Simplified Analogues of Lyngbyatoxin A: Use of an Isoxazoline-Based Indole Synthesis. Quest for Protein Kinase C Modulators
Kozikowski, Alan P.,Sato, Kazuo,Basu, Alakananda,Lazo, John S.
, p. 6228 - 6234 (1989)
Efficient synthetic routes to optically active analogues of lyngbyatoxin A, a potent activator of protein kinase C, have been devised starting from L-valine methyl ester.Access to the indole nucleus of these molecules is gained through the nitrile oxide based annelation of an aromatic ring to a pyrrole ring.The biological action of several of the intermediates and analogues preparated during the course of these studies on protein kinase C activity is also presented.
Synthetic chemistery, neurotransmission and second messengers
Kozikowski
, p. 97 - 105 (2007/10/02)
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