121818-29-9Relevant articles and documents
Selective terminal olefin oxidation of n-3 polyunsaturated fatty acids
Kato,Hirukawa,Namiki
, p. 1475 - 1478 (1992)
Through the action of N-bromosuccinimide in aqueous glyme, terminal double bond of n-3 fatty acids was selectively converted to the corresponding bromohydrin. This evidence suggests the tight conformation of the n-3 fatty acids in aqueous medium.
ALL-CIS-3,6,9,12,15-OCTADECAPENTAENOIC ACID FROM THE UNICELLULAR ALGA GYMNODINIUM KOWALEVSKII
Kuklev, D. V.,Aizdaicher, N. A.,Imbs, A. B.,Bezuglov, V. V.,Latyshev, N. A.
, p. 2401 - 2404 (1992)
All-cis-3,6,9,12,15-octadecapentaenoic acid (18:5n-3) was isolated from total lipids of the cultivated microalga Gymnodinium kowalevskii.Its structure was confirmed by GC-MS, 1HNMR, IR and synthesis using a modified method of iodolactonization from 22:6n-3. Key Word Index - Gymnodinium kowalevskii; Gymnodiniaceae; unicellular algae; marine lipids; octadecapentaenoic acid; synthesis.
PROCESSES IN THE PREPARATION OF POLYUNSATURATED KETONE COMPOUNDS
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, (2019/12/04)
A process comprising the following steps: a-i) treating a polyunsaturated ester with a base in a solvent of lower alcohol and water to form the corresponding polyunsaturated acid; a-ii) treating the product from step a-i), especially the crude product, with a halolactonization agent in the solvent of lower alcohol and water, to form the corresponding polyunsaturated halolactone; and a-iii) treating the product from step a-ii), especially the crude product, with a reagent in the solvent of lower alcohol and water to convert the polyunsaturated halolactone to the corresponding polyunsaturated epoxide lower alkyl ester.
PROCESS FOR THE PREPARATION OF A POLYUNSATURATED KETONE COMPOUND
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Page/Page column 21; 22, (2015/02/19)
The invention relates to the manufacture of certain polyunsaturated compounds employing a particular application of the Mitsonobu reaction in the presence of at least one anti-oxidant. We have found a method of making a pharmaceutically-acccptable polyunsaturated ester or thioester compound directly, which can ultimately be converted to the advantageous ketone compounds, in which unwanted oxidation and cis/trans isomerization are substantially reduced or eliminated using particular Mitsonobu chemistry.
