1228-72-4Relevant articles and documents
Nocke
, (1961)
Syntheses of 15α hydroxyestrone and 15α hydroxyestradiol
Hosoda,Yamashita,Nambara
, p. 3141 - 3145 (1975)
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PROCESS FOR THE PREPARATION OF ALOSETRON
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Page/Page column 3, (2012/07/27)
The present invention provides an improved process for the preparation of Alosetron of formula (I) and its pharmaceutically acceptable salts.
Medicaments
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, (2008/06/13)
The invention relates to the use of compounds of the general formula (I) STR1 and physiologically acceptable salts and solvates thereof, in which Im represents an imidazolyl group of formula: STR2 and R1 represents a hydrogen atom or a group selected from C1-6 alkyl, C3-6 alkenyl, C3-10 alkynyl, C3-7 cycloalkyl, C3-7 cycloalkylC1-4 alkyl, phenyl, phenylC1-3 alkyl, phenylmethoxymethyl, phenoxyethyl, phenoxymethyl, --CO2 R5, --COR5, --CONR5 R6 or --SO2 R5 (wherein R5 and R6, which may be the same or different each represents a hydrogen atom, a C1-6 alkyl or C3-7 cycloalkyl group, or a phenyl or phenylC1-4 alkyl group, in which the phenyl group is optionally substituted by one or more C1-4 alkyl, C1-4 alkoxy or hydroxy groups or halogen atoms, with the proviso that R5 does not represent a hydrogen atom when R1 represents a group --CO2 R5 or --SO2 R5); one of the groups represented by R2, R3 and R4 is a hydrogen atom or a C1-6 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, phenyl or phenylC1-3 alkyl group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C1-6 alkyl group; and n represents 2 or 3, for the treatment of a condition involving excessive eating, for example bulimia.
