122833-58-3Relevant articles and documents
Discovery of chiral cyclopropyl dihydro-alkylthio-benzyl-oxopyrimidine (5-DABO) derivatives as potent HIV-1 reverse transcriptase inhibitors with high activity against clinically relevant mutants
Radi, Marco,Maga, Giovanni,Alongi, Maddalena,Angeli, Lucilla,Samuele, Alberta,Zanoli, Samantha,Bellucci, Luca,Tafi, Andrea,Casaluce, Gianni,Giorgi, Gianluca,Armand-Ugon, Mercedes,Gonzalez, Emmanuel,Este, José A.,Baltzinger, Mireille,Bec, Guillaume,Dumas, Philippe,Ennifar, Eric,Botta, Maurizio
supporting information; experimental part, p. 840 - 851 (2009/12/26)
The role played by stereochemistry in the C2-substituent (left part) on the S-DABO scaffold for anti-HIV-1 activity has been investigated for the first time. A series of S-DABO analogues, where the double bond in the C2-substituent is replaced by an enant
A Catalytic Enantioselective Reaction Using a C2-Symmetric Disulfonamide as a Chiral Ligand: Alkylation of Aldehydes Catalyzed by Disulfonamide-Ti(O-i-Pr)4-Dialkyl Zinc System
Takahashi, Hideyo,Kawakita, Takashi,Ohno, Masaji,Yoshioka, Masato,Kobayashi, Susumu
, p. 5691 - 5700 (2007/10/02)
Excellent enantioselective alkylation of aldehydes with dialkylzinc has been developed.This methodology is based on the concept of modifying the Lewis acid with a C2-symmetric, electron-withdrawing disulfonamide.The chiral Lewis acid catalysts used in the present study are the titanium complexes, prepared in-situ from disulfonamide and Ti(O-i-Pr)4.Key Words: Chiral disulfonamide; chiral titanium complex; enantioselective alkylation; dialkyl zinc; catalytic reaction