122946-43-4 Usage
Description
Telmesteine is a new mucolytic agent possessing expectorant and secretolytic activity
introduced for the treatment of acute and chronic bronchitis. It is reported to have
anti-elastase activity and to show effectiveness in pulmonary emphysema.
Originator
Yason (Medea) (Italy)
Uses
Telmesteine is a useful agent for respiratory tract disorders; also it has been reported to be a critical active ingredient in topical compositions for dermatitis.
Brand name
Reolase; Muconorm
Check Digit Verification of cas no
The CAS Registry Mumber 122946-43-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,9,4 and 6 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 122946-43:
(8*1)+(7*2)+(6*2)+(5*9)+(4*4)+(3*6)+(2*4)+(1*3)=124
124 % 10 = 4
So 122946-43-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H11NO4S/c1-2-12-7(11)8-4-13-3-5(8)6(9)10/h5H,2-4H2,1H3,(H,9,10)
122946-43-4Relevant articles and documents
The use of Curtius rearrangement in the synthesis of 4- aminothiazolidines
Braibante, Mara E.F.,Braibante, Hugo S.,Costenaro, Edson R.
, p. 943 - 946 (2007/10/03)
The amine group of the L-cysteine was protected as (4R)-1,3- thiazolidines-4-carboxylic acids 2a-b and was used for the synthesis of functionalized 1,3-diamines by the way of Curtius reaction. An optimization of this methodology was made using the acylation in situ of the amine group of the thiazolidines and the activation of the carboxylic acid, after Curtius rearrangement yielded the ureas 7a,b and 8a and amine derivatives 6a,b. The Curtius reaction occurred without racemization, preserving the chemical and pharmacological importance of these products.
