122977-44-0 Usage
Description
(+)-MOD-DIOP, also known as (+)-2,3-O-Isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane, is a chiral diphosphine ligand that plays a crucial role in asymmetric catalysis. It features two diphenylphosphino groups connected to a central butane moiety, which includes two hydroxyl groups and an isopropylidene bridge. This unique structure allows (+)-MOD-DIOP to coordinate with transition metals, thereby facilitating enantioselective reactions across a range of catalytic processes, such as hydrogenation, allylic substitution, and C-C bond formation. Its high enantioselectivity and versatility have made it a popular choice among organic chemists for the synthesis of pharmaceuticals, agrochemicals, and fine chemicals, establishing it as a valuable asset in synthetic chemistry.
Uses
Used in Pharmaceutical Industry:
(+)-MOD-DIOP is used as a chiral ligand in asymmetric catalysis for the synthesis of enantiomerically pure pharmaceutical compounds. Its ability to coordinate with transition metals and promote enantioselective reactions ensures the production of the desired enantiomer, which is crucial for the efficacy and safety of many drugs, as different enantiomers can have different biological activities.
Used in Agrochemical Industry:
(+)-MOD-DIOP is utilized as a chiral ligand in the synthesis of agrochemicals, specifically for the production of enantiomerically pure active ingredients. This ensures that the agrochemicals are both effective and environmentally friendly, as the undesired enantiomers can sometimes have negative effects on non-target organisms.
Used in Fine Chemicals Industry:
(+)-MOD-DIOP is employed as a chiral ligand in the synthesis of fine chemicals, which are high-purity chemicals used in various applications, including fragrances, flavors, and specialty materials. Its high enantioselectivity ensures that the final products have the desired properties and meet the stringent purity requirements of these industries.
Used in Academic and Research Settings:
(+)-MOD-DIOP is used as a research tool in academic and industrial research settings to study and develop new asymmetric catalytic processes. Its unique structural features and excellent performance make it an ideal candidate for exploring novel reaction mechanisms and developing new synthetic methodologies.
Check Digit Verification of cas no
The CAS Registry Mumber 122977-44-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,2,9,7 and 7 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 122977-44:
(8*1)+(7*2)+(6*2)+(5*9)+(4*7)+(3*7)+(2*4)+(1*4)=140
140 % 10 = 0
So 122977-44-0 is a valid CAS Registry Number.
122977-44-0Relevant articles and documents
Hydroformylation process
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Page/Page column 4-5, (2008/06/13)
A process for the production of 4-hydroxybutyraldehyde is described. The process comprises reacting allyl alcohol with a mixture of carbon monoxide and hydrogen in the presence of a solvent and a catalyst system comprising a rhodium complex and a 2,3-O-isopropylidene-2,3-dihydroxy-1,4-bis[bis(3,5-di-n-alkylphenyl)phosphino]butane. The process gives high yield of 4-hydroxybutyraldehyde compared to 3-hydroxy-2-methylpropionaldehyde.
HIGHLY EFFICIENT ASYMMETRIC HYDROGENATION OF ITACONIC ACID DERIVATIVES CATALYZED BY A MODIFIED DIOP-RHODIUM COMPLEX
Morimoto, Toshiaki,Chiba, Mitsuo,Achiwa, Kazuo
, p. 735 - 738 (2007/10/02)
A modified DIOP analogue bearing 4-methoxy and 3,5-dimethyl groups on each phenyl group has been synthesized.The rhodium complex of the ligand has been found to give very high optical yields in the asymmetric hydrogenation of itaconic acid and its derivatives bearing β-aryl groups, the products of which are key-intermediates for optically active lignan derivatives.
