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123-25-1

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123-25-1 Usage

General Description

Diethyl succinate is a colorless, transparent liquid commonly used as a solvent and in the production of perfumes, flavors, and pharmaceuticals. It is also used as a synthetic intermediate in organic chemical reactions. Diethyl succinate is a diester, which means it is composed of two ester groups. It has a fruity odor and is relatively stable in normal conditions. It is considered to be non-toxic and non-irritating to the skin, but it may cause irritation to the respiratory system if inhaled in high concentrations. Diethyl succinate is not known to be carcinogenic or mutagenic, and it is not considered to pose a significant risk to the environment.

Check Digit Verification of cas no

The CAS Registry Mumber 123-25-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,2 and 3 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 123-25:
(5*1)+(4*2)+(3*3)+(2*2)+(1*5)=31
31 % 10 = 1
So 123-25-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H14O4/c1-3-11-7(9)5-6-8(10)12-4-2/h3-6H2,1-2H3

123-25-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Price
  • Detail
  • Alfa Aesar

  • (A15777)  Diethyl succinate, 98%   

  • 123-25-1

  • 100g

  • 200.0CNY

  • Detail
  • Alfa Aesar

  • (A15777)  Diethyl succinate, 98%   

  • 123-25-1

  • 500g

  • 315.0CNY

  • Detail
  • Alfa Aesar

  • (A15777)  Diethyl succinate, 98%   

  • 123-25-1

  • 10000g

  • 4741.0CNY

  • Detail
  • Sigma-Aldrich

  • (07429)  Diethylsuccinate  analytical standard

  • 123-25-1

  • 07429-5ML-F

  • 714.87CNY

  • Detail
  • Vetec

  • (V900593)  Diethylsuccinate  Vetec reagent grade, 98%

  • 123-25-1

  • V900593-100ML

  • 59.67CNY

  • Detail
  • Vetec

  • (V900593)  Diethylsuccinate  Vetec reagent grade, 98%

  • 123-25-1

  • V900593-500ML

  • 228.15CNY

  • Detail
  • Aldrich

  • (112402)  Diethylsuccinate  ReagentPlus®, 99%

  • 123-25-1

  • 112402-250G

  • 422.37CNY

  • Detail
  • Aldrich

  • (112402)  Diethylsuccinate  ReagentPlus®, 99%

  • 123-25-1

  • 112402-1KG

  • 918.45CNY

  • Detail

123-25-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name Diethyl succinate

1.2 Other means of identification

Product number -
Other names Succinic Acid Diethyl Ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:123-25-1 SDS

123-25-1Synthetic route

diethyl Fumarate
623-91-6

diethyl Fumarate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With hexacarbonyl molybdenum; phenylsilane In tetrahydrofuran for 4.5h; Heating;100%
With 1,2,2,3,4,4-hexamethylphosphetane 1-oxide; phenylsilane; water In toluene at 80℃; for 24h; Catalytic behavior; Solvent; Temperature; Reagent/catalyst; Schlenk technique; Inert atmosphere;99%
With acetic acid; zinc for 0.5h; Ambient temperature; sonication;98%
but-2-enedioic acid diethyl ester
1520-50-9

but-2-enedioic acid diethyl ester

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With 5% Pd/C; hydrogen In ethanol at 20℃; for 0.5h; chemoselective reaction;100%
With hydrogen In methanol at 24.84℃; under 760.051 Torr;
With silica gel supported sulfonic acid In acetonitrile at 20℃; Reagent/catalyst; Electrochemical reaction;75 %Spectr.
acetylenedicarboxylic acid diethyl ester
762-21-0

acetylenedicarboxylic acid diethyl ester

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethyl acetate at 80℃; under 2585.81 Torr; for 0.05h; microwave irradiation;99%
With magnesium chloride electrolysis: large surface area gold wire electrode; 150 W cm-2 ultrasound intensity; Yield given;
With water; zinc In tetrahydrofuran; methanol for 3h; Heating;100 % Spectr.
Diethyl maleate
141-05-9

Diethyl maleate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With acetic acid; zinc for 2h; Ambient temperature; sonication;98%
With Decaborane; palladium on activated charcoal In methanol at 25℃; for 0.3h; Reduction;98%
With 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-7-methylbenzo-[d]imidazole; [Zr(2,6-bis(5-methyl-3-phenyl-1H-pyrrol-2-yl)pyridine)2] In benzene-d6 for 8h; UV-irradiation;98%
ethanol
64-17-5

ethanol

succinic acid
110-15-6

succinic acid

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With alumina methanesulfonic acid at 80℃; for 0.133333h; Microwave irradiation;97%
With Fe(SO4)3 * xH2O In toluene for 3h; Heating;95%
With N-dodecanoyl-N-methyl-1-glucamine In water at 45℃; for 6h; Green chemistry;87%
Succinimide
123-56-8

Succinimide

ethanol
64-17-5

ethanol

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With chloro-trimethyl-silane at 40℃; for 5h;96%
With chloro-trimethyl-silane at 20 - 40℃; for 5h; Inert atmosphere;96%
1,2-bis(ethoxycarbonyl)vinyl toluene-p-sulfonate
144150-81-2

1,2-bis(ethoxycarbonyl)vinyl toluene-p-sulfonate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With sodium tetrahydroborate; nickel dichloride In methanol ice-cooling;92%
Diethyl maleate
141-05-9

Diethyl maleate

A

diethyl 2-n-butylsuccinate
24766-10-7

diethyl 2-n-butylsuccinate

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With aluminium trichloride; lithium di-n-butylcuprate In diethyl ether at -65 - -40℃; for 1h;A 1.8%
B 92%
With lithium di-n-butylcuprate In diethyl ether at -65 - -40℃; for 1h; Product distribution; in the presence of AlCl3 as well; other solvents;A 1%
B 57%
diethyl meso-2,3-dibromosuccinate
1114-31-4

diethyl meso-2,3-dibromosuccinate

A

diethyl Fumarate
623-91-6

diethyl Fumarate

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With sodium hydroxide; sodium tetrahydroborate; 1,2-di(thiophen-2-yl)ditelluride In ethanol; water at 5℃;A 90%
B n/a
ethanol
64-17-5

ethanol

C12H24O4Si
594815-54-0

C12H24O4Si

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
Stage #1: C12H24O4Si With oxalyl dichloride; N,N-dimethyl-formamide
Stage #2: ethanol With pyridine
83%
ethyl iodide
75-03-6

ethyl iodide

C12H24O4Si
594815-54-0

C12H24O4Si

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride83%
With tetrabutyl ammonium fluoride In tetrahydrofuran at 0℃;
ethanol
64-17-5

ethanol

4-oxopentanoic acid ethyl ester
539-88-8

4-oxopentanoic acid ethyl ester

A

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
Stage #1: 4-oxopentanoic acid ethyl ester With acetic acid at 120℃; for 6h;
Stage #2: ethanol for 6h; Reflux;
A 8.7%
B 80%
succinic acid
110-15-6

succinic acid

(2,2-diethoxyvinylidene)triphenylphosphorane
21882-77-9, 53472-13-2

(2,2-diethoxyvinylidene)triphenylphosphorane

A

ethyl (triphenylphosphoranylidene)acetate
1099-45-2

ethyl (triphenylphosphoranylidene)acetate

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
In tetrahydrofuran for 3h; Ambient temperature;A n/a
B 76%
diethyl sulphite
623-81-4

diethyl sulphite

succinic acid
110-15-6

succinic acid

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
sulfuric acid In ethanol Heating;73%
With mineral acid
cyclohexenone
930-68-7

cyclohexenone

1-iodocyclohexane
626-62-0

1-iodocyclohexane

O,O'-bistributyltin benzopinacolate
153094-32-7

O,O'-bistributyltin benzopinacolate

diethyl Fumarate
623-91-6

diethyl Fumarate

A

3-(hydroxydiphenylmethyl)cyclohexan-1-one
21086-38-4

3-(hydroxydiphenylmethyl)cyclohexan-1-one

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
In benzene at 80℃; for 8h;A 45%
B 72%
diethylmalate
7554-12-3

diethylmalate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide; Trimethylacetic acid In tetrahydrofuran at 20 - 22℃; for 2h;71%
bromo(2-ethoxy-2-oxoethyl)zinc
5764-82-9

bromo(2-ethoxy-2-oxoethyl)zinc

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With N,N-diethyl-N-bromoamine In tetrahydrofuran; diethyl ether at 20 - 25℃; Reagent/catalyst; Cooling; Inert atmosphere;71%
(2R,3R)-diethyl 2,3-bis(3,5-bis(trifluoromethyl)benzoyloxy)-succinate

(2R,3R)-diethyl 2,3-bis(3,5-bis(trifluoromethyl)benzoyloxy)-succinate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; N-ethyl-N,N-diisopropylamine In water; acetonitrile at 40℃; for 16h; Sealed tube; Schlenk technique; Inert atmosphere; Irradiation;69%
Diethyl maleate
141-05-9

Diethyl maleate

Bu2CuLi*AlCl3

Bu2CuLi*AlCl3

A

diethyl 2-n-butylsuccinate
24766-10-7

diethyl 2-n-butylsuccinate

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
In diethyl ether at -65 - -40℃; for 1h;A 9%
B 66%
Diethyl tartrate
408332-88-7

Diethyl tartrate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With phosphorus; hydrogen iodide In water; toluene at 80℃; for 1.5h; Inert atmosphere;65%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

O-tert-butyl O-ethyl ketene acetal
121745-78-6

O-tert-butyl O-ethyl ketene acetal

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With 2,4,6-trimethyl-pyridine; dilauryl peroxide In cyclohexane for 3h; Heating;64%
dimanganese decacarbonyl
10170-69-1

dimanganese decacarbonyl

ethyl bromoacetate
105-36-2

ethyl bromoacetate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
In chloroform-d1 Irradiation (UV/VIS); (N2 or Ar); 250-W sun lamp, 3 h; colorless solution is filtered, (1)H-NMR;64%
5-diazo-4-oxo-valeric acid ethyl ester
61844-36-8

5-diazo-4-oxo-valeric acid ethyl ester

phenyl copper
3220-49-3

phenyl copper

A

Ethyl 4-oxo-5-phenyl-pentanoate
20416-11-9

Ethyl 4-oxo-5-phenyl-pentanoate

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
for 1h; Ambient temperature;A 62%
B n/a
pyrrole
109-97-7

pyrrole

5-diazo-4-oxo-valeric acid ethyl ester
61844-36-8

5-diazo-4-oxo-valeric acid ethyl ester

A

ethyl 4-oxo-5-(2-pyrrolyl)-pentanoate
105886-77-9

ethyl 4-oxo-5-(2-pyrrolyl)-pentanoate

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With copper In benzene for 0.25h;A 61%
B n/a
diethyl acetylsuccinate
1115-30-6

diethyl acetylsuccinate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With 1,2-diamino-benzene at 140℃; for 4h;61%
1,3-cyclopentadione
3859-41-4

1,3-cyclopentadione

ethanol
64-17-5

ethanol

A

butanedioic acid, monoethyl ester
1070-34-4

butanedioic acid, monoethyl ester

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With potassium peroxomonosulfate at 20℃; for 18h;A 25%
B 61%
ethanol
64-17-5

ethanol

levulinic acid
123-76-2

levulinic acid

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With carbonic acid dimethyl ester at 180℃; under 10343.2 Torr; for 5h; Reagent/catalyst; Temperature; Inert atmosphere;60.2%
diethyl Fumarate
623-91-6

diethyl Fumarate

A

diethyl 2-acetylmethyl-1,4-butanedioate
1187-74-2

diethyl 2-acetylmethyl-1,4-butanedioate

B

3,7-Bis-ethoxycarbonyl-5-oxo-nonanedioic acid diethyl ester

3,7-Bis-ethoxycarbonyl-5-oxo-nonanedioic acid diethyl ester

C

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With sulfur dioxide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 80℃; for 1.25h;A 6.2%
B 10%
C 58%
N-ethyl-N,N-diisopropylamine
7087-68-5

N-ethyl-N,N-diisopropylamine

diethyl Fumarate
623-91-6

diethyl Fumarate

A

diethyl 2-acetylmethyl-1,4-butanedioate
1187-74-2

diethyl 2-acetylmethyl-1,4-butanedioate

B

3,7-Bis-ethoxycarbonyl-5-oxo-nonanedioic acid diethyl ester

3,7-Bis-ethoxycarbonyl-5-oxo-nonanedioic acid diethyl ester

C

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With sulfur dioxide In N,N-dimethyl acetamide at 80℃; for 3.5h;A 16%
B 14%
C 56%
Diethyl maleate
141-05-9

Diethyl maleate

A

diethyl Fumarate
623-91-6

diethyl Fumarate

B

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Conditions
ConditionsYield
With sulfur dioxide; N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 80℃; for 2.5h;A 10%
B 55%
formic acid ethyl ester
109-94-4

formic acid ethyl ester

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

diethyl 2-formylbutanedioate
5472-38-8

diethyl 2-formylbutanedioate

Conditions
ConditionsYield
With sodium In diethyl ether at 40℃; for 5h;100%
With sodium In diethyl ether at 40℃; for 5h;100%
With sodium hydride In toluene at 20℃; for 16h; Reagent/catalyst;95.1%
succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

Butane-1,4-diol
110-63-4

Butane-1,4-diol

Conditions
ConditionsYield
With C56H70Cl3N10Ru2(1+)*F6P(1-); potassium tert-butylate; hydrogen In tetrahydrofuran; dodecane at 70℃; under 37503.8 Torr; for 16h; Inert atmosphere; Glovebox; Autoclave;100%
With C30H34Cl2N2P2Ru; potassium methanolate; hydrogen In tetrahydrofuran at 100℃; under 38002.6 - 76005.1 Torr; for 15h; Glovebox; Autoclave;91%
With ethanol; sodium
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C10H10O4S

C10H10O4S

Conditions
ConditionsYield
Stage #1: thiophene-2-carbaldehyde; succinic acid diethyl ester With potassium tert-butylate In tert-butyl alcohol for 1.5h; Heating / reflux;
Stage #2: With hydrogenchloride; water In tert-butyl alcohol pH=2;
100%
3-methyl-1H-pyrazole-4-carbaldehyde
112758-40-4

3-methyl-1H-pyrazole-4-carbaldehyde

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

3-(ethoxycarbonyl)-4-(3-methyl-1H-pyrazol-4-yl)but-3-enoic acid
200264-80-8

3-(ethoxycarbonyl)-4-(3-methyl-1H-pyrazol-4-yl)but-3-enoic acid

Conditions
ConditionsYield
Stage #1: 3-methyl-1H-pyrazole-4-carbaldehyde; succinic acid diethyl ester With potassium tert-butylate; tert-butyl alcohol at 80℃; for 4h;
Stage #2: With hydrogenchloride In water pH=~ 2;
100%
3-ethyl-1H-pyrazole-4-carbaldehyde
154926-98-4

3-ethyl-1H-pyrazole-4-carbaldehyde

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C12H16N2O4

C12H16N2O4

Conditions
ConditionsYield
Stage #1: 3-ethyl-1H-pyrazole-4-carbaldehyde; succinic acid diethyl ester With potassium tert-butylate; tert-butyl alcohol at 80℃; for 3h;
Stage #2: With hydrogenchloride In water pH=~ 2;
100%
4-Benzoyl-7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran

4-Benzoyl-7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C24H26O6
1259401-36-9

C24H26O6

Conditions
ConditionsYield
Stage #1: 4-Benzoyl-7-methoxy-2,2-dimethyl-2,3-dihydrobenzofuran; succinic acid diethyl ester With potassium tert-butylate In tetrahydrofuran at 55℃; for 1h; Stobbe Condensation;
Stage #2: With hydrogenchloride In tetrahydrofuran; water
100%
C16H14F2N2O
1262589-95-6

C16H14F2N2O

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C22H22F2N2O4
1262590-20-4

C22H22F2N2O4

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 55℃; for 1h;100%
C15H14OS2
1263318-62-2

C15H14OS2

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C21H22O4S2
1263318-63-3

C21H22O4S2

Conditions
ConditionsYield
Stage #1: C15H14OS2; succinic acid diethyl ester With potassium tert-butylate In tetrahydrofuran at 55℃;
Stage #2: With hydrogenchloride In tetrahydrofuran; water
100%
C15H12O4

C15H12O4

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C21H20O7

C21H20O7

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 55℃; for 1h; Stobbe Condensation;100%
C25H25NO4
1395868-61-7

C25H25NO4

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C31H33NO7
1395872-59-9

C31H33NO7

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 55℃; for 1h;100%
C20H16OS

C20H16OS

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C26H24O4S

C26H24O4S

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 55℃; for 1h;100%
C16H16OS3

C16H16OS3

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C22H24O4S3

C22H24O4S3

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 55℃; for 1h;100%
C22H20O2S
1427470-15-2

C22H20O2S

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C28H28O5S
1427470-16-3

C28H28O5S

Conditions
ConditionsYield
Stage #1: C22H20O2S; succinic acid diethyl ester With potassium tert-butylate In tetrahydrofuran for 1h;
Stage #2: With hydrogenchloride In water
100%
bis(p-methylphenyl)-methanone
611-97-2

bis(p-methylphenyl)-methanone

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

2-Di-p-tolylmethylene-succinic acid 1-ethyl ester
95698-26-3

2-Di-p-tolylmethylene-succinic acid 1-ethyl ester

Conditions
ConditionsYield
With potassium tert-butylate In tetrahydrofuran at 55℃; for 1h;100%
furfural
98-01-1

furfural

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

3-(ethoxycarbonyl)-4-(furan-2-yl)-3-butenoic acid

3-(ethoxycarbonyl)-4-(furan-2-yl)-3-butenoic acid

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol at 110℃; for 3h; Inert atmosphere;99%
With potassium tert-butylate In tert-butyl alcohol for 1.5h; Stobbe condensation; Heating;
succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

succinic acid dihydrazide
4146-43-4

succinic acid dihydrazide

Conditions
ConditionsYield
With hydrazine hydrate In methanol for 8h; Reflux;98%
With hydrazine hydrate In ethanol for 12h; Reflux;65%
With ethanol; hydrazine hydrate
succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

lithium di-enolate of diethyl succinate

lithium di-enolate of diethyl succinate

Conditions
ConditionsYield
With lithium diisopropyl amide In tetrahydrofuran at -78℃; for 0.25h;98%
3,4-dimethoxy-benzaldehyde
120-14-9

3,4-dimethoxy-benzaldehyde

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

2-(3,4-dimethoxybenzylidene)butanedioic acid monoethyl ester
126274-95-1

2-(3,4-dimethoxybenzylidene)butanedioic acid monoethyl ester

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol for 3h; Heating;98%
With potassium tert-butylate In tert-butyl alcohol at 50℃; for 5h;
3,4-dimethoxy-benzaldehyde
120-14-9

3,4-dimethoxy-benzaldehyde

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

(E)-4-(3,4-dimethoxyphenyl)-3-(ethoxycarbonyl)but-3-enoic acid
182572-57-2

(E)-4-(3,4-dimethoxyphenyl)-3-(ethoxycarbonyl)but-3-enoic acid

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 4h; Stobbe Condensation; Inert atmosphere; Reflux;98%
With sodium ethanolate Stobbe Condensation; Reflux;96%
With sodium t-butanolate In tert-butyl alcohol Reflux;56%
With potassium tert-butylate In butan-1-ol at 20℃; for 3h; Stobbe condensation;
3,4-dichlorobenzophenone
6284-79-3

3,4-dichlorobenzophenone

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

3-ethoxycarbonyl-4-(3,4-dichlorophenyl)-4-phenyl-(Z)-but-3-enoic acid

3-ethoxycarbonyl-4-(3,4-dichlorophenyl)-4-phenyl-(Z)-but-3-enoic acid

Conditions
ConditionsYield
Stage #1: 3,4-dichlorobenzophenone; succinic acid diethyl ester In tert-butyl alcohol at 25 - 30℃;
Stage #2: With sodium hydride In tert-butyl alcohol at 85 - 90℃; for 4h;
Stage #3: With hydrogenchloride; water In hexane; ethyl acetate
98%
3-methoxy-4-(phenylmethoxy)benzaldehyde
2426-87-1

3-methoxy-4-(phenylmethoxy)benzaldehyde

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C21H22O6

C21H22O6

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 4h; Stobbe Condensation; Inert atmosphere; Reflux;98%
With sodium ethanolate for 4h; Stobbe condensation; Reflux;
3,4-dibenzyloxybenzaldehyde
5447-02-9

3,4-dibenzyloxybenzaldehyde

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

C27H26O6

C27H26O6

Conditions
ConditionsYield
With sodium ethanolate In ethanol for 4h; Stobbe Condensation; Inert atmosphere; Reflux;98%
succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

(+/-)-trans-5-benzyloxy-1,3-dimethyl-1H-isochromane-6-carbaldehyde

(+/-)-trans-5-benzyloxy-1,3-dimethyl-1H-isochromane-6-carbaldehyde

2-[1-((1S,3S)-5-Benzyloxy-1,3-dimethyl-isochroman-6-yl)-meth-(E)-ylidene]-succinic acid diethyl ester

2-[1-((1S,3S)-5-Benzyloxy-1,3-dimethyl-isochroman-6-yl)-meth-(E)-ylidene]-succinic acid diethyl ester

Conditions
ConditionsYield
With potassium tert-butylate In tert-butyl alcohol for 4h; Stobbe condensation; Heating;97%
ethyl [3H]formate
90009-92-0

ethyl [3H]formate

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

diethyl ([3H]formyl)succinate
1035845-94-3

diethyl ([3H]formyl)succinate

Conditions
ConditionsYield
With sodium ethanolate In toluene at 20℃;97%
3,5-dimethoxybenzaldehdye
7311-34-4

3,5-dimethoxybenzaldehdye

succinic acid diethyl ester
123-25-1

succinic acid diethyl ester

(E)-4-(3,5-dimethoxyphenyl)-3-(ethoxycarbonyl)but-3-enoic acid
607356-91-2

(E)-4-(3,5-dimethoxyphenyl)-3-(ethoxycarbonyl)but-3-enoic acid

Conditions
ConditionsYield
With ethanol; sodium hydride In toluene; mineral oil at 0 - 20℃; Inert atmosphere;97%

123-25-1Related news

Volumetric and viscometric study with FT-IR analysis of binary systems with Diethyl succinate (cas 123-25-1) and alcohols09/09/2019

Density, viscosity and refractive index of binary mixtures consisting of diethyl succinate + 1-propanol, or +1-butanol, or +1-hexanol have been measured at atmospheric pressure and over the temperature range from 288.15 K to 323.15 K. Excess and deviation functions have been calculated from thes...detailed

Phase equilibrium measurements and thermodynamic modeling of {CO2 + Diethyl succinate (cas 123-25-1) + cosolvent} systems09/07/2019

This work reports experimental phase equilibrium data for the binary systems {CO2(1) + diethyl succinate(2)} and {CO2(1) + ethyl acetate(2)}, and for the ternary systems {CO2(1) + diethyl succinate(2) + ethanol(3)} and {CO2(1) + diethyl succinate(2) + ethyl acetate(3)}. The experiments for the b...detailed

123-25-1Relevant articles and documents

Hickling,Westwood

, (1939)

Deactivation of Supported Nickel-Based Hydrogenation Catalysts with Sulfide Ions

Prozorov,Afineevskii,Knyazev,Sukhachev, Ya. P.,Sukhacheva

, p. 2158 - 2162 (2019)

Abstract: Kinetics of the liquid-phase hydrogenation of a multiple carbon bond is studied in an aqueous medium on supported nickel catalysts at different hydrogen pressures in the system under conditions of partly controlled deactivation of the active surface sites with sulfide ions. The pattern of deactivation of the active surface sites of Ni/SiO2 catalysts containing different amounts of the active metal on the surface with sulfide ions in water is determined. The resistance of the studied catalysts to deactivation during the reduction of diethyl maleate (DM) and propen-2-ol-1 is determined experimentally. It is shown that the catalyst is more resistant to deactivation during the hydrogenation of propen-2-ol-1; this finding is attributed to the steric factor. It is found that the hydrogen pressure in the system does not affect the deactivation pattern. Excessive pressure slightly alters the deactivation resistance of the catalyst during the hydrogenation of propen-2-ol-1. It is shown experimentally that the catalytic properties of nickel in liquid-phase hydrogenation reactions can be controlled by introducing small amounts of a catalytic poison into the system at high hydrogen pressures.

-

Kuwajima,I.,Doi,Y.

, p. 1163 - 1166 (1972)

-

-

Stout,G.H. et al.

, p. 4191 - 4200 (1968)

-

Robertson

, p. 2057 (1925)

Synthesis of a sulfated-group-riched carbonaceous catalyst and its application in the esterification of succinic acid and fructose dehydration to form HMF

Liu, Huihui,Peng, Qian,Ren, Jiawen,Shi, Bianfang,Wang, Yanqin

, p. 2649 - 2656 (2021)

A novel sulfated-group-riched sulfonated carbonaceous catalyst with high acidic strength and adjustable ratio of acidic groups was designed in the paper, where glucose and benzyl chloride were hydrothermally carbonized first followed by sulfonation treatment. Various physicochemical techniques were used to characterize the catalyst such as IR, 13C MAS NMR and XPS spectra, NH3-TPD, XRD patterns and TG curve. Then, it was applied in the esterification of succinic acid and fructose dehydration to form HMF. Compared to commercial Amberlyst-15 catalyst, such carbonaceous solid acid exhibited excellent catalytic activity and thermal stability, which was attributed to its higher amount of sulfonic acid group.

Vicinal alkylation-carboxymethylation of electron-poor alkenes by radical-chain reactions with O-alkyl O-silyl ketene acetals and their [3+2] annulation by reaction with O-cyclopropylcarbinyl O-silyl ketene acetals

Cai, Yudong,Roberts, Brian P.

, p. 1485 - 1488 (2004)

O-Silyl ketene acetals of the type H2C=C(OR)OSiMe 2But, in which R is a tertiary or secondary alkyl group, react with electron-poor alkenes to bring about vicinal alkylation- carboxymethylation of the latter. When R is a cyclopropyldimethylcarbinyl group such reactions take a more complex course involving ring opening of the cyclopropylcarbinyl radical and lead ultimately to [3+2] annulation of the alkene.

Synthesis and antiischemic activity of dicarboxylic nitroxyalkylamides and nitroxyalkylimides

Fedorov,Bogdanov,Fadeev,Lagodzinskaya

, p. 1119 - 1125 (2014)

A number of dicarboxylic N-(2-nitroxyalkyl)amides and N-(2-nitroxyalkyl)imides were synthesized and their antiischemic activity was studied. The ratio of the areas of necrotic and ischemic zones was used as a criterion for evaluation of antiischemic activity. The maximum values were close to antiischemic activity of Nicorandil, with acute toxicity of compounds synthesized being considerably lower.

Synthesis of 1,4-diketones: reaction of α-bromo ketones with tetrakis(dimethylamino)ethylene (TDAE)

Nishiyama, Yutaka,Kobayashi, Akihiro

, p. 5565 - 5567 (2006)

1,4-Diketones were prepared by the reaction of α-bromo ketones with tetrakis(dimethylamino)ethylene (TDAE) in moderate to good yields. Similarly, α-bromo esters were reductively coupled using TDAE to give the 1,4-diesters in moderate yields.

Rieke zinc as a reducing agent for common organic functional groups

Kroemer, Jeremy,Kirkpatrick, Chris,Maricle, Brian,Gawrych, Rick,Mosher, Michael D.,Kaufman, Don

, p. 6339 - 6341 (2006)

The ability of Rieke zinc to reduce common organic functional groups has been studied. Nitrobenzene, conjugated aldehydes, arylacetylenes, and phenylpropiolates are readily reduced under mild conditions. Benzonitrile, alkylacetylenes, ketones, unconjugated aldehydes, and alkenes are not reduced.

Zeolite Y from kaolin clay of Kachchh, India: Synthesis, characterization and catalytic application

Gandhi, Dolly,Bandyopadhyay, Rajib,Soni, Bhavna

, (2021/11/23)

Kaolin clay obtained from Kachchh, Gujarat was used as alumina and silica source to synthesize zeolite Y by hydrothermal method. The synthesis route comprised of the following steps: sulfuric acid treatment at 110 ?°C (4 ?h) for impurity removal followed by calcination at 600 ?°C for 4 ?h, thermal activation of kaolin into metakaolin by NaOH fusion at 850 ?°C (8 ?h); aging of reaction mixtures at 50 ?°C (24 ?h); crystallization (24 ?h) followed by washing and drying. The synthesized zeolite Y was examined by multiple characterization techniques which revealed a pore volume of 0.22 ?cm3/g with pore size of 2.89 ?nm having essential surface area of 320 ?m2/g, indicating a porous material having majority of micropores and remaining mesopores. The zeolite exhibited good catalytic activity for succinic acid esterification using ethanol to produce monoethyl and diethyl succinate. The conversion of SA (72%) and yield (60%) of valuable diester indicated good conversion rate and selectivity at moderate reaction conditions. Detailed structural comparison with zeolite Y synthesized using standard chemical route is also carried out. This work demonstrated an effective way of preparing environmentally benign porous zeolite Y having high surface area and pore volume that can be useful for catalytic applications.

Metal-free reduction of unsaturated carbonyls, quinones, and pyridinium salts with tetrahydroxydiboron/water

Li, Tiejun,Peng, Henian,Tang, Wenjun,Tian, Duanshuai,Xu, Guangqing,Yang, He

, p. 4327 - 4337 (2021/05/31)

A series of unsaturated carbonyls, quinones, and pyridinium salts have been effectively reduced to the corresponding saturated carbonyls, dihydroxybenzenes, and hydropyridines in moderate to high yields with tetrahydroxydiboron/water as a mild, convenient, and metal-free reduction system. Deuterium-labeling experiments have revealed this protocol to be an exclusive transfer hydrogenation process from water. This journal is

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