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1247-42-3

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1247-42-3 Usage

Chemical Properties

White Solid

Originator

Betapar,Parke Davis,US,1970

Uses

Different sources of media describe the Uses of 1247-42-3 differently. You can refer to the following data:
1. Corticosteroid.
2. Betapar(Meprednisone) is a glucocorticoid and a methylated derivative of prednisone. [1]The methylprednisone to MPL area under the curve ratio decreased from 0.19 +/- 0.04 in control to 0.14 +/- 0.03 in ketoconazole-treated rats (P less than .05) due to a

Manufacturing Process

16β-Methylprednisone 21-acetate (0.5 g), when hydrolyzed by means of aqueous alcoholic potassium bicarbonate yields 16β-ethylprednisone. An alternative method of the preparation of the compound of this example is as follows. Bacillus sphaericus var. fusifermis (A.T.C.C. 7055) is incubated on a nutrient agar (composed of Bacto-beef extract, 3 g; Bacto-peptone, 5 9; sodium chloride, 8 9; agar, 15 g; and tap water, 1 liter) for 24 hours at 28°C. To 100 ml of a sterile nutrient broth (composed of Bacto-beef extract, 3 9; Bacto-peptone, 5 9; per liter of tap water) in a 300 ml flask is added one loopful of the incubated culture and the broth mixture is further incubated for 24 hours at 28°C on a shaking machine. The broth culture so obtained is employed as an inoculum (1%). Into each of ten flasks containing 100 ml of sterile nutrient broth is added 1 ml of the inoculum. The flasks are agitated on a rotary shaker for 8 hours at 28°C at 240 strokes per minute. After this growth period, a solution of 25 mg of 16β-methylcortisonein 0.5 ml of methanol is aseptically added to each flask which in turn is reshaken and incubated for an additional 24 hours. The final pH is 7.8. The contents of the flasks are then combined and extracted 3 times with two liters of chloroform per extraction. The combined chloroform extracts are evaporated to dryness yielding 310 mg of crude product. The crude steroid is purified by chromatography on a chromatographic system described by G.M. Shull, Abstracts of Papers of the 126th Meeting of the American Chemical Society, December 12-17, 1954, page 9a, paper No. 24. Chromatographic evaluation shows a quantitative conversion of the starting material to the diene when an authentic sample of the 16β-methylprednisone is used as a control. Alternatively, the crude product is recrystallized from acetone affording 225 mg of 16β-methylprednisone.

Brand name

Betapar (Schering).

Therapeutic Function

Glucocorticoid

Check Digit Verification of cas no

The CAS Registry Mumber 1247-42-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,4 and 7 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1247-42:
(6*1)+(5*2)+(4*4)+(3*7)+(2*4)+(1*2)=63
63 % 10 = 3
So 1247-42-3 is a valid CAS Registry Number.
InChI:InChI=1/C22H28O5/c1-12-8-16-15-5-4-13-9-14(24)6-7-20(13,2)19(15)17(25)10-21(16,3)22(12,27)18(26)11-23/h6-7,9,12,15-16,19,23,27H,4-5,8,10-11H2,1-3H3/t12-,15-,16?,19?,20-,21-,22-/m0/s1

1247-42-3 Well-known Company Product Price

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  • USP

  • (1388005)  Meprednisone  United States Pharmacopeia (USP) Reference Standard

  • 1247-42-3

  • 1388005-200MG

  • 4,588.74CNY

  • Detail

1247-42-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name Meprednisone

1.2 Other means of identification

Product number -
Other names BETAPAR

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1247-42-3 SDS

1247-42-3Downstream Products

1247-42-3Related news

Comparative analysis the binding affinity of mycophenolic sodium and Meprednisone (cas 1247-42-3) with human serum albumin: Insight by NMR relaxation data and docking simulation08/04/2019

Mycophenolic sodium is an immunosuppressive agent that is always combined administration with corticosteroid in clinical practice. Considering the distribution and side-effect of the drug may change when co-administrated drug exist, this paper comparatively analyzed the binding ability of mycoph...detailed

1247-42-3Relevant articles and documents

-

Oliveto et al.

, p. 4428 (1958)

-

Methylprednisilone preparation method (by machine translation)

-

Paragraph 0013, (2017/04/28)

Methylprednisilone preparation method, is made up of 4 - androstenedione (abbreviated as 4AD) preparation of the 16 (17) a - epoxy prednison in organic solvent with the glycol in 10 - 50 °C shall ketal acid catalyzed reaction: 20 - shrinks the keto - 16a (17) - epoxy prednison; then the ketal in organic solvent with the three a chlorosilane silicon ether alkali catalytic reaction shall be: 21 - a silicon ether base - 20 - shrinks the keto - 16a (17) - epoxy prednison; then the silicon ether in organic solvent with the 2M methyl magnesium halide Grignard reaction, in the strong acid in the resulting standard hydrolyze methylprednisilone, HPLC content detected 99.0% or more, melting point 228 - 237 °C, synthetic weight total yield of 80 - 85%. To the invention producing methyl prednisone, raw material sources are extensive, process economic and environmental protection, simple and convenient production operation, short synthetic route, synthetic high yield, low production cost compared to the conventional method of 30 - 40%; is favorable for industrial production. (by machine translation)

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