124752-25-6

• 

• Basic information

  1. Product Name: 6-aminocarbovir
  2. Synonyms: 6-aminocarbovir;(-)-2,6-Diamino-9-[(1R)-4β-(hydroxymethyl)-2-cyclopentene-1β-yl]-6,9-dihydro-1H-purine;2-Cyclopentene-1-methanol, 4-(2,6-diamino-9H-purin-9-yl)-, (1S-cis)-;Descyclopropyl Abacavir;Abacavir Related Compound A (20 mg) ([4-(2,6-diamino-9H-purin-9-yl)cyclopent-2-enyl]methanol);(1S,4R)-4-(2,6-DiaMino-9H-purin-9-yl)-2-cyclopentene-1-Methanol;Abacavir Related CoMpound A
  3. CAS NO:124752-25-6
  4. Molecular Formula: C₁₁H₁₄N₆O
  5. Molecular Weight: 246.26846
  6. EINECS: N/A
  7. Product Categories: Bases & Related Reagents;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
  8. Mol File: 124752-25-6.mol
  9. Article Data: 9

• Chemical Properties

  1. Melting Point: 180-182°C
  2. Boiling Point: 628.2°Cat760mmHg
  3. Flash Point: 333.7°C
  4. Appearance: /
  5. Density: 1.75g/cm³
  6. Vapor Pressure: 1.21E-16mmHg at 25°C
  7. Refractive Index: 1.866
  8. Storage Temp.: -20?C Freezer
  9. Solubility: DMSO (Slightly), Methanol (Slightly, Heated)
  10. PKA: 14.86±0.10(Predicted)
  11. CAS DataBase Reference: 6-aminocarbovir(CAS DataBase Reference)
  12. NIST Chemistry Reference: 6-aminocarbovir(124752-25-6)
  13. EPA Substance Registry System: 6-aminocarbovir(124752-25-6)

• Safety Data

  1. Hazard Codes: Xi
  2. Statements: 41-43
  3. Safety Statements: 26-36/37-39
  4. WGK Germany:
  5. RTECS:
  6. HazardClass: N/A
  7. PackingGroup: N/A
  8. Hazardous Substances Data: 124752-25-6(Hazardous Substances Data)

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• (1S,4R)-4-(2,6-Diamino-9H-purin-9-yl)-2-cyclopentene-1-methanol

  Cas No: 124752-25-6

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• Dayang Chem (Hangzhou) Co.,Ltd.
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• Abacavir Related Compound A (20 mg) ([4-(2,6-diamino-9H-purin-9-yl)cyclopent-2-enyl]methanol)

  Cas No: 124752-25-6

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• Henan Allgreen Chemical Co.,Ltd
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• 6-aminocarbovir CAS No.124752-25-6

  Cas No: 124752-25-6

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• Guangdong Juda Chemical Industrial Co.,Limited
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• Descyclopropyl Abacavir

  Cas No: 124752-25-6

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• BOC Sciences
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• 6-aminocarbovir

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• ZHEJIANG JIUZHOU CHEM CO.,LTD
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• Abacavir EP Impurity C (Abacavir Related Compound A) with high purity >98% in stock CAS 124752-25-6

  Cas No: 124752-25-6

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• 10 Milligram

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• Topbatt Chemical Co., Ltd.
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• Abacavir EP Impurity C

  Cas No: 124752-25-6

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• 1 Gram

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• Shandong Bolode Bio-Technology Co., LTD
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• Abacavir Imp A (Abacavir USP RC A)(Descyclopropyl Abacavir)

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• Simson Pharma Limited
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• Descyclopropyl Abacavir

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• Finetech Industry Limited
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• Abacavir Impurity C

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• Changzhou Hopschain Chemical Co.,Ltd
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124752-25-6 Usage

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Different sources of media describe the Uses of 124752-25-6 differently. You can refer to the following data:
1. Descyclopropyl Abacavir (Abacavir EP Impurity C; Abacavir Related Compound A) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2''-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.
2. Abacavir Intermediate.

Check Digit Verification of cas no

The CAS Registry Mumber 124752-25-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,4,7,5 and 2 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 124752-25:
(8*1)+(7*2)+(6*4)+(5*7)+(4*5)+(3*2)+(2*2)+(1*5)=116
116 % 10 = 6
So 124752-25-6 is a valid CAS Registry Number.

InChI:InChI=1/C11H14N6O/c12-9-8-10(16-11(13)15-9)17(5-14-8)7-2-1-6(3-7)4-18/h1-2,5-7,18H,3-4H2,(H4,12,13,15,16)/t6-,7+/m1/s1

124752-25-6 Well-known Company Product Price

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• USP

• (1000420)  Abacavir Related Compound A  United States Pharmacopeia (USP) Reference Standard

• 124752-25-6

• 1000420-20MG

• 14,578.20CNY

• Detail

124752-25-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name	(1α,4α)-4-(2,6-Diamino-9H-purin-9-yl)-2-cyclopentenyl-carbinol

1.2 Other means of identification

Product number	-
Other names	ABACAVIR RELATED COMPOUND

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:124752-25-6 SDS

124752-25-6Upstream product

• 172015-79-1 ((1S,4R)-4-(2-amino-6-chloro-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol hydrochloride 
• 268737-87-7 ((1S,4R)-4-(2,6-dichloro-9H-purin-9-yl)cyclopent-2-en-1-yl)methanol 
• 162992-44-1 9-[cis-(1'R,4'S)-4'-acetoxymethyl-2'-cyclopenten-1'-yl]-9H-2-amino-6-chloropurine 
• 120443-30-3 carbovir 
• 136522-33-3 (1S,4R)-4-[2-amino-6-chloro-9H-purin-9-yl]-2-cyclopentene-1-methanol 

124752-25-6Downstream Products

124752-25-6Relevant articles and documents

6-deoxycarbovir: A xanthine oxidase activated prodrug of carbovir

Vince,Brownell,Beers

, p. 39 - 44 (1995)

(-)-(cis)-4-(2-Amino-9H-purin-9-yl)-2-cyclopentenyl carbinol (6-deoxycarbovir) was prepared in order to evaluate prodrug approaches to increased bioavailability of the anti-HIV agent, (-)-carbovir. Incubation experiments demonstrated that 6-deoxycarbovir was rapidly converted to (-)-carbovir by the enzyme, xanthine oxidase. Since xanthine oxidase activity is present in both the intestine and liver, a high first pass conversion to carbovir would be expected in vivo.

CYCLOPENTENYL PURINE DERIVATIVE OR SALT THEREOF

-

Paragraph 0296-0299, (2021/05/28)

An object of the present invention is to provide a compound exhibiting an excellent drug efficacy as an anti-adenoviral agent, and an anti-adenoviral agent. The present invention provides an anti-adenoviral agent including a compound represented by General Formula [1] (in the formula, R1 represents a hydrogen atom, a halogen atom, an amino group which may be substituted, a monocyclic nitrogen-containing heterocyclic ring group which may be substituted (provided that a nitrogen atom forming the ring is bonded to a carbon atom to which R1 is bonded), a monocyclic nitrogen- and oxygen-containing heterocyclic ring group which may be substituted (provided that a nitrogen atom forming the ring is bonded to a carbon atom to which R1 is bonded), a C1-6 alkoxy group which may be substituted, a hydroxyl group which may be protected, or the like; R2 represents a hydrogen atom or an amino protecting group; R3 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like; R4 represents a C1-20 alkoxy group which may be substituted, an aryloxy group which may be substituted, an amino group which may be substituted, or the like; and X represents an oxygen atom or a sulfur atom) or a salt thereof.

Analogs of (1s,cis)-4-(2-amino-9h-purin -9-yl) -2-Cyclopentene-1-methanol as antiviral

-

, (2008/06/13)

The present invention relates to analogs of (1S, cis)-4-(2-amino-9H-purin-9-yl)-2-cyclopentene-1-methanol for use in treating viral infections.

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