124935-88-2Relevant articles and documents
Copper-catalysed selective hydroamination reactions of alkynes
Shi, Shi-Liang,Buchwald, Stephen L.
, p. 38 - 44 (2015/04/14)
The development of selective reactions that utilize easily available and abundant precursors for the efficient synthesis of amines is a long-standing goal of chemical research. Despite the centrality of amines in a number of important research areas, including medicinal chemistry, total synthesis and materials science, a general, selective and step-efficient synthesis of amines is still needed. Here, we describe a set of mild catalytic conditions utilizing a single copper-based catalyst that enables the direct preparation of three distinct and important amine classes (enamines, ±-chiral branched alkylamines and linear alkylamines) from readily available alkyne starting materials with high levels of chemo-, regio-and stereoselectivity. This methodology was applied to the asymmetric synthesis of rivastigmine and the formal synthesis of several other pharmaceutical agents, including duloxetine, atomoxetine, fluoxetine and tolterodine.
A PROCESS FOR THE PREPARATION OF TOLTERODINE TARTRATE
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Paragraph 175-182, (2010/09/03)
The present invention relates to provide a process for the preparation of (+)-(R)-Tolterodine-L-tartrate, comprises a step of aminating hydroxyl protected 3-(2-methoxy-5-methylphenyl)-3-phenyl propanol of formula (V) with diisopropylamine in the presence of water to obtain N, N-diisopropyl-3-(2-methoxy-5-methylphenyl)-3-phenylpropyl amine of formula (VI).
Process for producing tolterodine
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Page/Page column 9; 9-10, (2010/11/28)
The present invention provides a process for producing tolterodine of the formula (1) or its salt, which comprises a step reacting a compound of the formula (2) with a base to obtain a reaction product; a step reacting the reaction product with a compound
