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125056-75-9

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125056-75-9 Usage

General Description

The chemical 1-[(2-hydroxyethoxy)methyl]-5-methyl-6-{[3-(trifluoromethyl)phenyl]sulfanyl}pyrimidine-2,4(1H,3H)-dione is a compound with a molecular formula C14H14F3N3O4S. It contains a pyrimidine ring with a sulfanyl group attached to a trifluoromethylphenyl group at position 6, and a 1-[(2-hydroxyethoxy)methyl]-5-methyl substituent at position 1. This chemical is a pyrimidine derivative that may have potential applications in pharmaceutical research and development due to its structural features and potential biological activities. Additional studies are needed to fully understand its properties and potential uses.

Check Digit Verification of cas no

The CAS Registry Mumber 125056-75-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,0,5 and 6 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 125056-75:
(8*1)+(7*2)+(6*5)+(5*0)+(4*5)+(3*6)+(2*7)+(1*5)=109
109 % 10 = 9
So 125056-75-9 is a valid CAS Registry Number.

125056-75-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2-hydroxyethoxymethyl)-5-methyl-6-[3-(trifluoromethyl)phenyl]sulfanylpyrimidine-2,4-dione

1.2 Other means of identification

Product number -
Other names 2,4(1H,3H)-Pyrimidinedione,1-[(2-hydroxyethoxy)methyl]-5-methyl-6-[[3-(trifluoromethyl)phenyl]thio]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:125056-75-9 SDS

125056-75-9Downstream Products

125056-75-9Relevant articles and documents

Structure-Activity Relationships of 1--6-(phenylthio)thymine Analogues: Effect of Substitutions at the C-6 Phenyl Ring and at the C-5 Position on Anti-HIV-1 Activity

Tanaka, Hiromichi,Takashima, Hideaki,Ubasawa, Masaru,Sekiya, Kouichi,Nitta, Iasei,et al.

, p. 337 - 345 (2007/10/02)

The effect of substitution on the pyrimidine moiety of 1--6-(phenylthio)thymine (HEPT) and 1--6-(phenylthio)-2-thiothymine (HEPT-S) on anti-HIV-1 activity was investigated by synthesizing a series of 5-methyl-6-(arylthio) and 5-substituted-6-(phenylthio) derivatives.Preparation of the 5-methyl-6-(arylthio) derivatives was carried out based on either LDA lithiation of 1-methyl>thymine (3) and 1-methyl>-2-thiothymine (4) followed by reaction with diaryl disulfides or an addition-elimination reaction of 1-methyl>-6-(phenylsulfinyl)thymine (31) with aromatic thiols.Preparation of the 5-substituted-6-(phenylthio) derivatives was carried out based on either C-5 lithiation of the 1-methyl>-6-(phenylthio)uracil (41) with LTMP or the LDA lithiation of 5-alkyl-1-methyl>-2-thiouracil derivatives 45-47.Substitution at the meta position of the C-6-(phenylthio) ring by the methyl group improved the original anti-HIV-1 activity of HEPT, and introduction of two m-methyl groups to the phenylthio ring further potentiated the activity -1-thymine (28), 0.26 μM; 6--1--2-thiothymine (30), 0.22 μM>.When the 5-methyl group was replaced by an ethyl or an isopropyl group, the anti-HIV-1 activity of HEPT was also improved remarkably -6-(phenylthio)-2-thiouracil (48), 0.11 μM; 5-isopropyl-1--6-(phenylthio)-2-thiouracil (50), 0.059 μM; 5-ethyl-1--6-(phenylthio)-2-thiouracil (54), 0.12 μM; 5-isopropyl-1--6-(phenylthio)-2-thiouracil (56), 0.063 μM>. 6--5-ethyl-1-thymine derivatives 51 and 57 and 6--5-isopropyl-1-thymine derivatives 52 and 58 inhibited the replication of HIV-1 in the nanomolar concentration range.

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