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125709-03-7

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125709-03-7 Usage

Description

(9xi,17xi)-6,9-difluoro-11-hydroxy-16-methyl-3-oxo-20-thioxopregna-1,4-dien-17-yl acetate is a synthetic corticosteroid derived from the glucocorticoid family, specifically a derivative of prednisolone. It is characterized by its potent anti-inflammatory and immunosuppressive properties, which are attributed to its ability to inhibit the production of chemicals responsible for inflammation and immune system responses in the body.

Uses

Used in Pharmaceutical Industry:
(9xi,17xi)-6,9-difluoro-11-hydroxy-16-methyl-3-oxo-20-thioxopregna-1,4-dien-17-yl acetate is used as an anti-inflammatory and immunosuppressive agent for the treatment of various inflammatory and immune-related conditions. Its application is primarily due to its ability to effectively reduce inflammation and suppress the immune system, providing relief from symptoms associated with these conditions.
Used in Treatment of Allergic Disorders:
This corticosteroid is used as a therapeutic agent for allergic disorders, as it helps in reducing the immune system's overreaction to allergens, thereby alleviating symptoms such as itching, redness, and swelling.
Used in Skin Condition Treatment:
(9xi,17xi)-6,9-difluoro-11-hydroxy-16-methyl-3-oxo-20-thioxopregna-1,4-dien-17-yl acetate is utilized in the treatment of various skin conditions, including eczema, dermatitis, and psoriasis. Its anti-inflammatory properties help in reducing skin inflammation, itching, and redness.
Used in Respiratory Disease Management:
(9xi,17xi)-6,9-difluoro-11-hydroxy-16-methyl-3-oxo-20-thioxopregna-1,4-dien-17-yl acetate is employed as a medication for respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), where it helps in reducing inflammation in the airways and improving lung function.
Used in Rheumatic Disorder Treatment:
(9xi,17xi)-6,9-difluoro-11-hydroxy-16-methyl-3-oxo-20-thioxopregna-1,4-dien-17-yl acetate is used as an anti-inflammatory and immunosuppressive agent in the treatment of rheumatic disorders, such as rheumatoid arthritis and lupus. It helps in reducing joint inflammation, pain, and swelling, thereby improving the patient's quality of life.
The acetate form of this compound allows for better absorption in the body and can be administered via various routes, including oral, topical, or injection, making it a versatile and effective treatment option for a wide range of inflammatory and immune-related conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 125709-03-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,7,0 and 9 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 125709-03:
(8*1)+(7*2)+(6*5)+(5*7)+(4*0)+(3*9)+(2*0)+(1*3)=117
117 % 10 = 7
So 125709-03-7 is a valid CAS Registry Number.

125709-03-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name [(6S,8S,9R,10S,13S,14S,16S,17R)-17-ethanethioyl-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate

1.2 Other means of identification

Product number -
Other names 17-Methylthiocarbonyl-6,9-difluoro-11,17-dihydroxy-16-methylandrosta-1,4-diene-3-one 17-acetate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:125709-03-7 SDS

125709-03-7Downstream Products

125709-03-7Relevant articles and documents

Thiol Esters from Steroid 17β-Carboxylic Acids: Carboxylate Activation and Internal Participation by 17α-Acylates

Kertesz, Denis J.,Marx, Michael

, p. 2315 - 2328 (2007/10/02)

The chemistry of the steroid 17β-carboxylic acids derived from 16,17α-disubstituted corticosteroids was investigated with respect to thiol ester formation.Major quantities of 17-spiro byproducts were observed in the reactions of 16-methyl-17α-acyloxy acids, and the degree of 17-ester participation leading to these structures was dependent on the carboxylate activating group used and stereochemistry at C-16.Diethyl phosphate mixed anhydrides of these acids reacted with mercaptide salts to give mixtures of thiol esters with 17-spiro acylthio ortho esters, which predominated and were particularly stable in the case of 16β-methyl substrates; in addition, considerable reversion of 16α-methyl phosphate intermediates to starting acid was experienced.The use of diphenyl chlorophosphate as the activating agent greatly improved yields of thiol esters.Methanolysis of the phosphate adducts derived from 17α-acyloxy acids gave 17-spiro acyl ortho esters as the exclusive products.The reactions of 17α-acetoxy acids with 2-fluoro-N-methylpyridinium tosylate (FMPT) gave novel 17-spiro acyl fluoro ketals 32-35, whereas similar treatment of 17-hydroxy acids led to products of dehydration or of 18-methyl migration, including the novel 13,17-β-lactones 39 and 41.Activation with carbonyldiimidazole followed by addition of mercaptans allowed the preparation of thiol ester products from 17-hydroxy acids, but the method was restricted to use with these substrates.Neighbouring-group participation was not possible for the 16,17-acetonide acid 10, and activation with either cllorophosphate diesters or FMPT followed by reaction with methanethiolate gave high yields of methylthio ester 17.

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