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1259-86-5

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  • Picras-3-ene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-15-[(2S)-2-hydroxy-2-methyl-1-oxobutoxy]-, (1b,11b,12a,15b)- (9CI)

    Cas No: 1259-86-5

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  • Picras-3-ene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-15-[(2S)-2-hydroxy-2-methyl-1-oxobutoxy]-, (1b,11b,12a,15b)- (9CI)

    Cas No: 1259-86-5

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  • Picras-3-ene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-15-[(2S)-2-hydroxy-2-methyl-1-oxobutoxy]-, (1b,11b,12a,15b)- (9CI)

    Cas No: 1259-86-5

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  • Picras-3-ene-2,16-dione,11,20-epoxy-1,11,12-trihydroxy-15-[(2S)-2-hydroxy-2-methyl-1-oxobutoxy]-, (1b,11b,12a,15b)- (9CI) cas 1259-86-5

    Cas No: 1259-86-5

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1259-86-5 Usage

General Description

Glaucarubinone is a chemical compound that belongs to the quassinoids group, a type of natural product extracted from various plant species. It is particularly known for its potential anti-cancer properties and has been widely investigated for therapeutic uses against different types of cancers, including leukemia, breast cancer, and pancreatic cancer. Glaucarubinone exhibits its anti-cancer properties by inducing apoptotic cell death and inhibiting cell proliferation in the cancer cells. Additionally, it has been shown to have potent anti-protozoal activity, making it a significant chemical compound in the field of medical research. Despite its potential benefits, its use in humans is limited due to its toxicity.

Check Digit Verification of cas no

The CAS Registry Mumber 1259-86-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,2,5 and 9 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1259-86:
(6*1)+(5*2)+(4*5)+(3*9)+(2*8)+(1*6)=85
85 % 10 = 5
So 1259-86-5 is a valid CAS Registry Number.
InChI:InChI=1/C25H34O10/c1-6-22(4,31)21(30)35-16-15-11(3)17(27)25(32)20-23(5)12(10(2)7-13(26)18(23)28)8-14(34-19(16)29)24(15,20)9-33-25/h7,11-12,14-18,20,27-28,31-32H,6,8-9H2,1-5H3/t11-,12+,14-,15-,16-,17-,18-,20-,22+,23-,24+,25+/m1/s1

1259-86-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name Butyric acid, 2-hydroxy-2-methyl-, 4-ester with 1,3ab,4,7,7aa,11,11a,11ba-octahydro-1a,2a,4b,11b-tetrahydroxy-3a,8,11ab-trimethyl-2H-1,11cb-(epoxymethano)phenanthro[10,1-bc]pyran-5,10(3H,6abH)-dione

1.2 Other means of identification

Product number -
Other names glaucarubinone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:1259-86-5 SDS

1259-86-5Upstream product

1259-86-5Downstream Products

1259-86-5Related news

Structure de la glaucarubinone (cas 1259-86-5) nouveau principe amer isole de Simaruba glauca08/11/2019

RésuméUn nouveau principe amer, la Glaucarubinone, a été isolé des graines de Simaruba glauca. Il est montré que cette substance a la formule (IIa).detailed

glaucarubinone (cas 1259-86-5) inhibits colorectal cancer growth by suppression of hypoxia-inducible factor 1α and β-catenin via a p-21 activated kinase 1-dependent pathway08/10/2019

p-21-Activated kinase 1 (PAK1) enhances colorectal cancer (CRC) progression by stimulating Wnt/β-catenin, ERK and AKT pathways. PAK1 also promotes CRC survival via up-regulation of hypoxia-inducible factor 1α (HIF-1α), a key player in cancer survival. Glaucarubinone, a quassinoid natural prod...detailed

glaucarubinone (cas 1259-86-5) and gemcitabine synergistically reduce pancreatic cancer growth via down-regulation of P21-activated kinases08/09/2019

Pancreatic cancer is one of the most lethal of human malignancies. Nearly 100% cases of pancreatic cancer carry mutations in KRas. P-21-activated kinases (PAKs) are activated by and act downstream of KRas. Glaucarubinone, a natural product first isolated from the seeds of the tree Simarouba glau...detailed

1259-86-5Relevant articles and documents

Synthetic studies on quassinoids: Total synthesis of (-)-chaparrinone, (- )-glaucarubolone, and (+)-glaucarubinone

Grieco,Collins,Moher,Fleck,Gross

, p. 6078 - 6093 (2007/10/02)

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