1259-86-5Relevant articles and documents
Synthetic studies on quassinoids: Total synthesis of (-)-chaparrinone, (- )-glaucarubolone, and (+)-glaucarubinone
Grieco,Collins,Moher,Fleck,Gross
, p. 6078 - 6093 (2007/10/02)
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Version: 1.0
Creation Date: Aug 17, 2017
Revision Date: Aug 17, 2017
Product name | Butyric acid, 2-hydroxy-2-methyl-, 4-ester with 1,3ab,4,7,7aa,11,11a,11ba-octahydro-1a,2a,4b,11b-tetrahydroxy-3a,8,11ab-trimethyl-2H-1,11cb-(epoxymethano)phenanthro[10,1-bc]pyran-5,10(3H,6abH)-dione |
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Product number | - |
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Other names | glaucarubinone |
Identified uses | For industry use only. |
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Uses advised against | no data available |
Emergency phone number | - |
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Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
More Details:1259-86-5 SDS
RésuméUn nouveau principe amer, la Glaucarubinone, a été isolé des graines de Simaruba glauca. Il est montré que cette substance a la formule (IIa).detailed
p-21-Activated kinase 1 (PAK1) enhances colorectal cancer (CRC) progression by stimulating Wnt/β-catenin, ERK and AKT pathways. PAK1 also promotes CRC survival via up-regulation of hypoxia-inducible factor 1α (HIF-1α), a key player in cancer survival. Glaucarubinone, a quassinoid natural prod...detailed
Pancreatic cancer is one of the most lethal of human malignancies. Nearly 100% cases of pancreatic cancer carry mutations in KRas. P-21-activated kinases (PAKs) are activated by and act downstream of KRas. Glaucarubinone, a natural product first isolated from the seeds of the tree Simarouba glau...detailed
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