126382-02-3Relevant articles and documents
Total synthesis of cyclopiamide A and speradine E
Nakhla, Mina C.,Weeks, Kendall N.,Navarro Villalobos, Mauricio,Wood, John L.
, p. 5085 - 5088 (2018)
Described is a total synthesis of the related alkaloids, cyclopiamide A and speradine E, via a unified strategy that also delivers the natural product aspergilline A. Key steps include metal-free conversion of a malonyl chloride and propargylamine to an intermediate pyrrolinone and a palladium catalyzed decarboxylation/aromatization sequence that delivers the requisite tetracyclic core.