126409-25-4Relevant articles and documents
Ring-closing metathesis strategy to unsaturated γ- and δ-lactones: Synthesis of hydroxyethylene isostere for protease inhibitors
Ghosh, Arun K.,Cappiello, John,Shin, Dongwoo
, p. 4651 - 4654 (2007/10/03)
Ring-closing olefin metathesis of acrylates derived from allylic and homo allylic alcohols in the presence of the Grubbs' catalyst (10-15 mol%) and titanium isopropoxide (0.3-3 equiv) provided ready access to α, β- unsaturated γ and δ-lactones and an important dipeptide isostere intermediate.
A Stereoselective Method for the Preparation of HIV-1 Protease Inhibitors Based on the Lewis Acid Mediated Reaction of Allylsilanes and N-Boc-α-amino Aldehydes
D'Aniello, Fabiana,Taddei, Maurizio
, p. 5247 - 5250 (2007/10/02)
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An Efficient Synthesis of Hydroxyethylene Dipeptide Isosteres: The Core Unit of Potent HIV-1 Protease Inhibitors
Ghosh, Arun K.,McKee, Sean P.,Thompson, Wayne J.
, p. 6500 - 6503 (2007/10/02)
An efficient and stereocontrolled synthesis of hydroxyethylene dipeptide isosteres 1 from commercially available, optically pure D-mannose is described.This synthesis represents a practical and enantioselective entry to a range of other dipeptide isostere