126463-64-7
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Basic information
- Product Name: dihydroeponemycin
- Synonyms: dihydroeponemycin
- CAS NO:126463-64-7
- Molecular Formula: C20H36N2O6
- Molecular Weight: 400.50964
- EINECS: N/A
- Product Categories: N/A
- Mol File: 126463-64-7.mol
- Article Data: 0
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: off-white to light tan/
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: 2-8°C
- Solubility: DMSO: ≥1mg/mL
- CAS DataBase Reference: dihydroeponemycin(CAS DataBase Reference)
- NIST Chemistry Reference: dihydroeponemycin(126463-64-7)
- EPA Substance Registry System: dihydroeponemycin(126463-64-7)
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Safety Data
- Hazard Codes: Xn
- Statements: 22
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 126463-64-7(Hazardous Substances Data)
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126463-64-7 Usage
Description
Dihydroeponemycin is a natural, irreversible inhibitor of proteasomal degradation of proteins that acts by binding the IFN-γ-inducible proteins LMP2 and LMP7, as well as the constitutive proteasome subunit X. It potently inhibits both the chymotrypsin-like and PGPH activity, with 10-fold less inhibition of trypsin-like activity. Dihydroeponemycin does not inhibit calpain or trypsin and has minor effects on cathepsin B and chymotrypsin at higher concentrations. It is cell-permeable and induces apoptosis in bovine aortic endothelial cells.Check Digit Verification of cas no
The CAS Registry Mumber 126463-64-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,4,6 and 3 respectively; the second part has 2 digits, 6 and 4 respectively.Calculate Digit Verification of CAS Registry Number 126463-64:
(8*1)+(7*2)+(6*6)+(5*4)+(4*6)+(3*3)+(2*6)+(1*4)=127
127 % 10 = 7
So 126463-64-7 is a valid CAS Registry Number.
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dihydroeponemycin
