126484-96-6Relevant articles and documents
THE SYNTHESIS AND CHARACTERIZATION OF 2,3-METHANOPYROGLUTAMIC ACID
Mapelli, Claudio,Elrod, Luther F.,Holt, Elizabeth M.,Stammer, Charles H.
, p. 4377 - 4382 (2007/10/02)
Details of the synthesis of 2,3-methanopyroglutamic acid (1), its N-methylamide (7) and N-β-naphthylamide (6) are reported.An NMR study of the conformation of 7 is discussed and the stability of the amide 6 to pyroglutamylaminopeptidase is detailed.The crystal structure of an alkene (4) formed during the pyrolysis of an intermediate pyrazoline (2) indicates that the (Z)-configuration is conserved during nitrogen extrusion.