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126522-16-5

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126522-16-5 Usage

General Description

2-AMINO-3,6-DIMETHOXYBENZENECARBALDEHYDE is a chemical compound with the molecular formula C10H11NO3. It is a derivative of benzaldehyde and contains two methoxy and one amino group attached to its benzene ring. 2-AMINO-3,6-DIMETHOXYBENZENECARBALDEHYDE is used in the synthesis of various pharmaceuticals and organic compounds through its aldehyde and amine functional groups. It has also been studied for its potential biological activities, including antifungal properties. Additionally, it is utilized in the development of fluorescent probes for imaging applications in biology and medicine.

Check Digit Verification of cas no

The CAS Registry Mumber 126522-16-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,6,5,2 and 2 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 126522-16:
(8*1)+(7*2)+(6*6)+(5*5)+(4*2)+(3*2)+(2*1)+(1*6)=105
105 % 10 = 5
So 126522-16-5 is a valid CAS Registry Number.

126522-16-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-amino-3,6-dimethoxybenzaldehyde

1.2 Other means of identification

Product number -
Other names Benzaldehyde,2-amino-3,6-dimethoxy

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:126522-16-5 SDS

126522-16-5Relevant articles and documents

Discovery of 5-(pyridin-3-yl)-1H-indole-4,7-diones as indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors

Kong, Kai-min,Liu, Bing-zhi,Meng, Guang-rong,Zhang, Jia-wei,Zhang, Qian

supporting information, (2020/01/03)

Early studies demonstrated that over expression of indoleamine 2,3-dioxygenase (IDO1) in tumor microenvironment results in tumor immune escape. Herein, in order to simplify the structure of two kinds of IDO1 inhibitors from marine alkaloid, Exiguamine A and Tsitsikammamines, we designed, synthesized a series of 1H-indole-4,7-dione derivatives and evaluated their inhibitory activity in IDO1 enzyme and in IFN-γ stimulated Hela cells in vitro. The structure-activity relationship demonstrated that 5-(pyridin-3-yl)-1H-indole-4,7-dione is a promising scaffold for IDO1 inhibitors and most compounds with this core showed moderate inhibition potency at micromole level. Our further enzyme kinetics experiments reveal that these new developed compounds might act as reversible competitive inhibitors of IDO1.

Efficient synthesis of novel six-member ring-fused quinoline derivatives via the Friedlaender reaction

Yang, Dingqiao,Guo, Wei,Cai, Yuepeng,Jiang, Lasheng,Jiang, Kailing,Wu, Xiaobing

, p. 229 - 233 (2008/09/19)

Novel quinolines fused with a six-member ring 5a-j were prepared in high yields (75-95%) via the Friedlaender reaction of dimethoxy-substituted o-aminobenzaldehydes of 3a or 3b with cyclic ketones 4, respectively. The structures of 5aj were determined by IR, 1H NMR, MS, and elemental analysis.

Incorporation of Quinoline-5,8-quinone Moiety into Polyaza Cavities

Thummel, Randolph P.,Chirayil, Sara,Hery, Christophe,Lim, Jean-Luc,Wang, Tie-Lin

, p. 1666 - 1671 (2007/10/02)

Silica gel supported nitric acid treatment of 2,5-dimethoxybenzaldehyde followed by reduction with iron powder provides 3,6-dimethoxy-2-aminobenzaldehyde.Friedlaender condensation of this species with a variety of ketones and diketones leads to 5,8-dimethoxyquinoline derivatives which may be oxidized by ceric ammonium nitrate (CAN) and pyridine-2,6-dicarboxylic acid N-oxide (PDANO) to the corresponding quinones.The quinone functionality can be incorporated into larger cavities by a selective stepwise Friedlaender approach and the CAN/PDANO oxidation appears to work preferentially for 5,8-dimethoxyquinoline.

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