127408-31-5 Usage
Uses
Y-26763, is a Kir6 (KATP) channel opener. It also inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. In vivo, it has shown to have hypotension activity in rats and cardioprotective properties in dogs.
Biological Activity
K ATP channel opener and active metabolite of Y-27152 (N-[(3S,4R)-6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-(phenylmethoxy)acetamide ). In vitro, causes relaxation of contracted rat aortic rings (IC 50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic b-cells. In vivo, produces hypotension in spontaneously hypertensive rats and displays cardioprotective properties in dogs following systemic administration.
Check Digit Verification of cas no
The CAS Registry Mumber 127408-31-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,4,0 and 8 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 127408-31:
(8*1)+(7*2)+(6*7)+(5*4)+(4*0)+(3*8)+(2*3)+(1*1)=115
115 % 10 = 5
So 127408-31-5 is a valid CAS Registry Number.
InChI:InChI=1/C14H16N2O4/c1-8(17)16(19)12-10-6-9(7-15)4-5-11(10)20-14(2,3)13(12)18/h4-6,12-13,18-19H,1-3H3/t12-,13+/m1/s1