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127492-36-8

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127492-36-8 Usage

General Description

(1E)-1,2-dideoxy-1-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-D-erythro-pent-1-enitol is a complex chemical compound with a long and specific name. It is a derivative of dioxo-dihydropyrimidin and D-erythro-pent-1-enitol. The compound is primarily used in pharmaceutical research and has potential therapeutic applications. Its precise chemical structure and properties make it a valuable tool for understanding the interactions and effects of similar compounds in biological systems. More research and study may reveal further applications and uses for this chemical in the medical field.

Check Digit Verification of cas no

The CAS Registry Mumber 127492-36-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,7,4,9 and 2 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 127492-36:
(8*1)+(7*2)+(6*7)+(5*4)+(4*9)+(3*2)+(2*3)+(1*6)=138
138 % 10 = 8
So 127492-36-8 is a valid CAS Registry Number.

127492-36-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name (E)-1-(3(S),4(R),5-trihydroxypent-1-en-1-yl)uracil

1.2 Other means of identification

Product number -
Other names 1-((E)-(3S,4R)-3,4,5-Trihydroxy-pent-1-enyl)-1H-pyrimidine-2,4-dione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:127492-36-8 SDS

127492-36-8Downstream Products

127492-36-8Relevant articles and documents

Synthesis and Anti-HIV Evaluation of 2',3'-Dideoxyribo-5-chloropyrimidine Analogues: Reduced Toxicity of 5-Chlorinated 2',3'-Dideoxynucleosides

Aerschot, Arthur Van,Everaert, Dirk,Balzarini, Jan,Augustyns, Koen,Jie, Liu,at al.

, p. 1833 - 1839 (2007/10/02)

In view of the selective anti-HIV activity of 2',3'-dideoxy-3'-fluoro-5-chlorouridine (11), a series of eight 2',3'-dideoxy-5-chloropyrimidines were synthesized and evaluated for their inhibitory activity against human immunodeficiency virus type 1 (HIV-1) replication in MT-4 cells.A marked improvement in selectivity was noted for the 5-chlorouracil derivatives of 2,3-dideoxyribofuranose, 3-azido-2,3-dideoxyribofuranose, and 3-fluoro-2,3-dideoxyribofuranose, mainly due to decreased toxicity of the compounds for the host cells.While chlorination of 2',3'-dideoxycytidine remo ved the anti-HIV activity, introduction of chlorine at the C-5 position of 3'-fluoro-, 3'-azido- or 2',3'-didehydro-2',3'-dideoxycytidine led to reduced cytotoxicity with only slightly reduced anti-HIV activity.X-ray analysis showed compound 11 to have two molecules in the asymmetric unit with κ = -168.8(3) deg and -131.3(3) deg and P = 179(1) deg and 163(1) deg, respectively; thus revealing no close resemblance to 3'-azido-3'-deoxythymidine (AZT).

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