129468-53-7Relevant articles and documents
A Short Route to 3'-Deoxy-3'-fluorothymidine
Motawia, Mohammed S.,Pedersen, Erik B.
, p. 1137 - 1139 (2007/10/02)
The 5-OH protected methyl glycosides 2 and 3 were epimerized to give the corresponding epimers 6 and 7 via an oxidation-reduction procedure.Reaction of 6 with diethylaminosulfur trifluoride (DAST) afforded the fluoro sugar 8, which was coupled with thymine to give 3'-deoxy-3'-fluorothymidine (12) after deprotection with saturated ammonia in methanol.