129560-00-5Relevant articles and documents
Design, synthesis, and insecticidal evaluation of new pyrazole derivatives containing imine, oxime ether, oxime ester, and dihydroisoxazoline groups based on the inhibitor binding pocket of respiratory complex i
Song, Hongjian,Liu, Yuxiu,Xiong, Lixia,Li, Yongqiang,Yang, Na,Wang, Qingmin
, p. 8730 - 8736 (2013)
On the basis of complex I receptor protein binding site and commercial tebufenpyrad and tolfenpyrad, four series of novel pyrazole-5-carboxamides containing imine, oxime ether, oxime ester, and dihydroisoxazoline were designed and synthesized via the key intermediate 4-chloro-3-ethyl-N-(4-formylbenzyl)-1- methyl-1H-pyrazole-5-carboxamide. The structures of target compounds were confirmed by 1H NMR and high-resolution mass spectrum (HRMS). The results of bioassays indicated that the target compounds possessed good-to-excellent activities against a broad spectrum of insects such as cotton bollworm (Helicoverpa armigera), spider mite (Tetranychus cinnabarinus), bean aphid (Aphis craccivora), and mosquito (Culex pipiens pallens), but gave different structure-activity relationships for each species. Compounds containing imine showed high insecticidal activity against cotton bollworm. Especially, stomach activity of compounds 5-1c was 60% at 11 mg kg-1. The compounds also had good activities against bean aphid and mosquito. The foliar contact activity of compounds 5-1a, 5-1b, 5-1e, 5-3c, and 5-3d against bean aphid were 90, 100, 90, 90, and 90%, respectively, at 200 mg kg -1. The activity of compound containing dihydroisoxazoline moiety (5-4) against mosquito was 60% at 1 mg kg-1, which was near that of tebufenpyrad. The introduction of dihydroisoxazoline structure (5-4) was advantageous to improve the activity of the compound against adult mites compared with other structures; the miticidal activity of 5-4- against adult mites was 60% at 50 mg kg-1.
Synthesis, Nematicidal Activity, and Molecular Docking of Some New Pyrazole-5-carboxamide Derivatives
Kang, Sheng-Jie,Zhao, Wen,Tan, Cheng-Xia,Weng, Jian-Quan,Peng, Wei-Li,Liu, Xing-Hai
, p. 51 - 56 (2021/04/22)
A series of new pyrazole-5-carboxamide compounds was synthesized. All the title pyrazole-5-carboxamide compounds were confirmed by nuclear magnetic resonance and mass spectrometry. The primarily nematicidal bioassay results showed that some of them exhibit low activity against Meloidogyne incognita at 10 ppm. In addition, the molecular docking simulation results indicated that compound 6b interacts with succinate dehydrogenase through two hydrogen bonds, which may provide useful information for further design novel nematicides.
Fluorobenzobishydrazide azole compound and application thereof
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Paragraph 0021; 0028-0030, (2020/06/09)
The invention discloses a fluorobenzobishydrazide azole azole compound. The compound has a structure as shown in a general formula I which is described in the specification. In the general formula I,Ph is one selected from substances as described in the s
