131184-64-0 Usage
General Description
1-(1-(2-benzodioxanylmethyl)-4-piperidiyl)amino-3-(1-naphthoxy)-2-propanol is a chemical compound that is derived from both benzodioxane and naphthoxy. Its molecular formula is C28H33NO4, and it has a molecular weight of 459.57 g/mol. 1-(1-(2-benzodioxanylmethyl)-4-piperidiyl)amino-3-(1-naphthoxy)-2-propanol is often used in the field of pharmacology and can act as a potent inhibitor of serotonin and norepinephrine reuptake. It has been studied for its potential use in the treatment of various medical conditions, including depression and anxiety disorders. However, further research is needed to determine its safety and efficacy for these purposes.
Check Digit Verification of cas no
The CAS Registry Mumber 131184-64-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,1,8 and 4 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 131184-64:
(8*1)+(7*3)+(6*1)+(5*1)+(4*8)+(3*4)+(2*6)+(1*4)=100
100 % 10 = 0
So 131184-64-0 is a valid CAS Registry Number.
InChI:InChI=1/C27H32N2O4/c30-22(18-31-25-11-5-7-20-6-1-2-8-24(20)25)16-28-21-12-14-29(15-13-21)17-23-19-32-26-9-3-4-10-27(26)33-23/h1-11,21-23,28,30H,12-19H2
131184-64-0Relevant articles and documents
Synthesis of the new α- and β-adrenergic antagonist 1-[1-(2-benzodioxanylmethyl)-4-piperidyl]amino-3-(1-naphthoxy)-2- propanol
Mauleon,Antunez,Rosell
, p. 1109 - 1117 (2007/10/02)
The synthesis and in vitro α- and β-adrenergic blocking potency of 1-[1-(2-benzodiaxanylmethyl)-4-piperidyl]amino-3-(1-naphthoxy)-2- propanol (I) are described. Thus, N-benzyl-4piperidone was protected and debenzylated to the carbamate (V), which upon alkaline hydrolysis and acylation gave benzodioxanic amide (IX). Reduction of the amide group, deprotection of the ketone function of (X), and reductive amination gave the 4-aminopiperidine (XIII), which was finally condensed with the appropriate epoxide to yield the aminopropanol (I). Compound (I) is formally derived from a combination of piperoxan (II) and propranolol (III), and was approximately 10 times less potent than each one of these drugs, as an α- and β-adrenergic blocker respectively.
