13189-98-5 Usage
Description
Different sources of media describe the Description of 13189-98-5 differently. You can refer to the following data:
1. Fudostein was launched in Japan as a new mucoactive agent for the
treatment of bronchitis and respiratory congestion. This cysteine derivative was obtained
from L-cysteine by condensation with either allylic alcohol in the presence of potassium
persulfate or the corresponding bromoalcohol in the presence of a base. Fudostein was
shown to significantly reduce mucus glycoprotein hypersecretion and inhibit infiltration of
airway mucosa by lymphocytes and inflammatory cells in bronchitic rats. When given to
bronchitic rabbits, an oral dose of 500 mg/kg daily potently decreased the fucose/ N-acetylneuraminic
acid in sputa, so exhibiting mucoregulatory properties. In another study
with SO2-exposed rabbits, fudostein suppressed blood flow of tracheal microvasculature
increased by SO2, partly due to scavenging of superoxide anion.
2. Fudosteine is a cysteine derivative that interferes with the increase in goblet cell number, expression of the mucin MUC5AC, and subsequent mucin secretion, in airways agonized with tobacco smoke, isoproterenol, lipopolysaccharide, TNF-α, or oxidants. Fudosteine, which is a thiol compound with antioxidant properties, limits NF-κB signaling and reduces inflammatory gene expression. It has greater bioavailability than N-acetyl-cysteine and increases cysteine levels in cells.
Chemical Properties
Off-White Powder
Originator
SS Pharmaceutical/Mitsubishi Pharma (Japan)
Uses
Different sources of media describe the Uses of 13189-98-5 differently. You can refer to the following data:
1. An antiinflammatory expectorant MUC5 mucin obstructive pulmonary disease.
2. Fudosteine is a novel mucoactive agent and a MUC5AC mucin hypersecretion inhibitor. MUC5AC mucin synthesis and the expression of the MUC5AC gene were increased by LPS in rats or TNF-α in NCI-H292 cells; these effects were inhibited by fudosteine treatment
3. An antiinflammatory expectorant used in the treatment of MUC5 mucin obstructive pulmonary disease.
4. A demonstrated antiinflammatory
5. Fudosteine is a cysteine derivative that interferes with the increase in goblet cell number, expression of the mucin MUC5AC, and subsequent mucin secretion, in airways agonized with tobacco smoke, isoproterenol, lipopolysaccharide, TNF-α, or oxidants. Fudosteine, which is a thiol compound with antioxidant properties, limits NF-κB signaling and reduces inflammatory gene expression. It has greater bioavailability than N-acetyl-cysteine and increases cysteine levels in cells.
Brand name
Cleanal
Hazard
A reproductive hazard.
Check Digit Verification of cas no
The CAS Registry Mumber 13189-98-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,1,8 and 9 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 13189-98:
(7*1)+(6*3)+(5*1)+(4*8)+(3*9)+(2*9)+(1*8)=115
115 % 10 = 5
So 13189-98-5 is a valid CAS Registry Number.
InChI:InChI=1/C6H13NO3S/c7-5(6(9)10)4-11-3-1-2-8/h5,8H,1-4,7H2,(H,9,10)