13239-97-9 Usage
Description
2-Thiocytidine, also known as 2-S-Cytidine, is a cytidine analogue with a sulfur atom replacing the oxygen atom at the 2nd position of the pyrimidine ring. It has been identified as a profiled metabolite in high-fat diet-induced obese mice after oral administration of Huangjinya green tea extract.
Uses
Used in Pharmaceutical Industry:
2-Thiocytidine is used as a potential therapeutic agent for various diseases, including cancer and viral infections. Its unique chemical structure allows it to interact with biological targets, such as enzymes and nucleic acids, and modulate their functions.
Used in Cancer Research:
2-Thiocytidine is used as a research tool in cancer biology to study the mechanisms of action and potential therapeutic applications. It can be employed to investigate the role of nucleotide metabolism and its regulation in cancer cells, as well as to identify potential targets for cancer therapy.
Used in Antiviral Research:
2-Thiocytidine is used as an antiviral agent in the study of viral replication and pathogenesis. It can be utilized to explore the mechanisms of viral resistance to current antiviral drugs and to develop novel therapeutic strategies against viral infections.
Used in Drug Development:
2-Thiocytidine is used as a lead compound in the development of new drugs targeting various diseases. Its unique chemical properties and biological activities make it a promising candidate for further optimization and drug design efforts.
Check Digit Verification of cas no
The CAS Registry Mumber 13239-97-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,2,3 and 9 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 13239-97:
(7*1)+(6*3)+(5*2)+(4*3)+(3*9)+(2*9)+(1*7)=99
99 % 10 = 9
So 13239-97-9 is a valid CAS Registry Number.
InChI:InChI=1/C9H13N3O4S/c10-5-1-2-12(9(17)11-5)8-7(15)6(14)4(3-13)16-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,17)
13239-97-9Relevant articles and documents
SYNTHESIS AND STRUCTURE OF HIGH POTENCY RNA THERAPEUTICS
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, (2019/01/15)
This invention provides expressible polynucleotides, which can express a target protein or polypeptide. Synthetic mRNA constructs for producing a protein or polypeptide can contain one or more 5′ UTRs, where a 5′ UTR may be expressed by a gene of a plant. In some embodiments, a 5′ UTR may be expressed by a gene of a member of Arabidopsis genus. The synthetic mRNA constructs can be used as pharmaceutical agents for expressing a target protein or polypeptide in vivo.
Straightforward pyrimidine ring construction: A versatile tool for the synthesis of nucleobase and nucleoside analogues
Robin, Aelig,Julienne, Karine,Meslin, Jean-Claude,Deniaud, David
, p. 634 - 643 (2007/10/03)
A general route to 1,2,4-trisubstituted pyrimidines is described in one to three steps from a common key precursor, diazadienium iodide 2. An efficient preliminary [4+2] cyclocondensation reaction between the azabutadiene building block 2 and various iso(thio)cyanates constitutes an original construction of the pyrimidine skeleton. Subsequent structural modifications on the heterocycle allow the elaboration of a 1-substituted pyrimidine library that includes nucleoside analogues. Wiley-VCH Verlag GmbH & Co. KGaA, 2006.
Optical properties of thiopyrimidine nucleosides.
Ueda,Nishino
, p. 920 - 926 (2007/10/07)
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