133008-08-9Relevant articles and documents
Reductive spiroannulation of nitriles with secondary electrophiles
Morin, Matthew D.,Rychnovsky, Scott D.
, p. 2051 - 2053 (2005)
(Chemical Equation Presented) The scope of reductive decyanation and spiroannulation reactions has been expanded to include secondary electrophiles for potentially useful transformations. Secondary phosphates and chlorides, as well as terminal epoxides, c
One-pot, two-step synthesis of unnatural α-amino acids involving the exhaustive aerobic oxidation of 1,2-diols
Inada, Haruki,Furukawa, Keisuke,Shibuya, Masatoshi,Yamamoto, Yoshihiko
, p. 15105 - 15108 (2019/12/26)
Herein, we report the nor-AZADO-catalyzed exhaustive aerobic oxidations of 1,2-diols to α-keto acids. Combining oxidation with transamination using dl-2-phenylglycine led to the synthesis of free α-amino acids (AAs) in one pot. This method enables the rapid and flexible preparation of a variety of valuable unnatural AAs, such as fluorescent AAs, photoactivatable AAs, and other functional AAs for bioorthogonal reactions.
Unified total synthesis of pteriatoxins and their diastereomers
Matsuura, Fumiyoshi,Peters, Rene,Anada, Masahiro,Harried, Scott S.,Hao, Junliang,Kishi, Yoshito
, p. 7463 - 7465 (2007/10/03)
A unified total synthesis is reported to access all of the possible diastereomers of pteriatoxins A-C, with the use of an intramolecular Diels-Alder reaction as the key step to form the carbo-macrocyclic core structure. The C34/C35-diol protecting groups were found to have significant effects on both the exo/endo-selectivity and the exo-facial selectivity of the intramolecular Diels-Alder process. Copyright