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134612-84-3

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134612-84-3 Usage

Uses

(4-Chlorophenyl)(3,4-dihydroxyphenyl)methanone is used because it showed inhibitory activity against protein tyrosine kinase as detected by structure-activity relationship.

Preparation

preparation by demethylation of 4′-chloro-4-hydroxy-3-methoxybenzophenone with hydrobromic acid in refluxing aqueous acetic acid.

Check Digit Verification of cas no

The CAS Registry Mumber 134612-84-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,6,1 and 2 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 134612-84:
(8*1)+(7*3)+(6*4)+(5*6)+(4*1)+(3*2)+(2*8)+(1*4)=113
113 % 10 = 3
So 134612-84-3 is a valid CAS Registry Number.

134612-84-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (4-chlorophenyl)-(3,4-dihydroxyphenyl)methanone

1.2 Other means of identification

Product number -
Other names 4'-CHLORO-3,4-DIHYDROXYBENZOPHENONE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:134612-84-3 SDS

134612-84-3Downstream Products

134612-84-3Relevant articles and documents

Synthesis and biological activity of halophenols as potent antioxidant and cytoprotective agents

Zhao, Wanyi,Feng, Xiue,Ban, Shurong,Lin, Wenhan,Li, Qingshan

supporting information; experimental part, p. 4132 - 4134 (2010/08/20)

A series of new bromophenols and chlorophenols were prepared by a practical route. The in vitro antioxidative activity of the halophenols was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, and their cytoprotective activity was also tested on hydrogen peroxide (H2O2)-induced injury in human umbilical vein endothelial cells (HUVEC). All halophenols tested displayed moderate to good DPPH radical-scavenging activity, and two bromophenols, 2,3′-dibromo-4,5,6′-trihydroxydiphenylmethanone (16c) and 2,3-dibromo-4,5-dihydroxydiphenylmethanone (17c) exhibited high protective activity against H2O2-induced injury in HUVEC with EC50 values of 0.4 and 0.8 μM, respectively. The preliminary structure-activity relationships of these compounds were also investigated in order to determine the essential structures required for their bioactivities.

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