13484-66-7 Usage
General Description
The chemical compound [(2R,3R,4R,5R)-5-[6-(benzylamino)purin-9-yl]-3,4-dihydroxy-oxolan-2-yl ]methoxyphosphonic acid, also known as tenofovir disoproxil, is a nucleotide reverse transcriptase inhibitor used to treat HIV/AIDS and chronic hepatitis B. It is a prodrug of tenofovir, which is phosphorylated within cells to its active form, tenofovir diphosphate. Once activated, tenofovir diphosphate inhibits the action of the enzyme reverse transcriptase, which the virus needs to replicate its genetic material. This ultimately suppresses the replication of the virus, slowing down its spread in the body and helping to reduce the progression of the disease. Tenofovir disoproxil is commonly used in combination with other antiretroviral medications to effectively manage HIV/AIDS.
Check Digit Verification of cas no
The CAS Registry Mumber 13484-66-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,3,4,8 and 4 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 13484-66:
(7*1)+(6*3)+(5*4)+(4*8)+(3*4)+(2*6)+(1*6)=107
107 % 10 = 7
So 13484-66-7 is a valid CAS Registry Number.
InChI:InChI=1/C17H20N5O7P/c23-13-11(7-28-30(25,26)27)29-17(14(13)24)22-9-21-12-15(19-8-20-16(12)22)18-6-10-4-2-1-3-5-10/h1-5,8-9,11,13-14,17,23-24H,6-7H2,(H,18,19,20)(H2,25,26,27)/p-2/t11-,13-,14-,17-/m1/s1
13484-66-7Relevant articles and documents
Identification of non-lipid LPA3 antagonists by virtual screening
Fells, James I.,Tsukahara, Ryoko,Fujiwara, Yuko,Liu, Jianxiong,Perygin, Donna H.,Osborne, Daniel A.,Tigyi, Gabor,Parrill, Abby L.
, p. 6207 - 6217 (2008)
In the present study, we utilized virtual screening to identify LPA3 antagonists. We have developed a three-point structure-based pharmacophore model based on known LPA3 antagonists. This model was used to mine the NCI database. Docking, pharmacophore development, and database mining produced new, non-lipid leads. Experimental testing of seven computationally selected pharmacophore hits produced one potentiator and three antagonists, one of which displays both LPA3 selectivity and nanomolar potency. Similarity searching in the ChemBridge database using the most promising lead as the search target produced four additional LPA3 antagonists and a potent dual LPA1&2 antagonist.
Platelet aggregation inhibitors. 4. N 6 -substituted adenosines.
Kikugawa,Iizuka,Ichino
, p. 358 - 364 (2007/10/09)
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