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134877-42-2

134877-42-2

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  • 2-Deoxy-2,2-difluoro-α-D-erythro-pentofuranose-3,5-dibenzoate-1-methanesulfonate

    Cas No: 134877-42-2

  • USD $ 1.2-5.0 / Kiloliter

  • 5 Kiloliter

  • 3000 Metric Ton/Month

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  • pharmaceutical intermediates 2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate Cas 134877-42-2

    Cas No: 134877-42-2

  • USD $ 3.0-3.0 / Gram

  • 1 Gram

  • 10 Metric Ton/Month

  • Hebei yanxi chemical co.,LTD.
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134877-42-2 Usage

Description

2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate is a chemical compound derived from α-D-erythro-pentofuranose, which is an impurity of Gemcitabine (G305028), a potential anticancer agent. 2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate is characterized by its unique molecular structure, which includes a ribofuranose core with deoxy and difluoro substitutions, as well as a methanesulfonate group and two benzoate moieties.

Uses

Used in Pharmaceutical Industry:
2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate is used as an impurity in the development and production of Gemcitabine (G305028), a potential anticancer agent. Its presence in the synthesis process of Gemcitabine is crucial for the compound's effectiveness as an anticancer drug. The compound plays a role in modulating the activity and potency of Gemcitabine, making it a valuable component in the pharmaceutical industry's pursuit of novel cancer treatments.
Used in Research and Development:
In addition to its application in the pharmaceutical industry, 2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate is also utilized in research and development efforts aimed at understanding the mechanisms of action and potential side effects of Gemcitabine. By studying the properties and interactions of this compound, researchers can gain insights into the broader class of nucleoside analogs and their potential applications in cancer therapy.
Used in Quality Control and Regulatory Compliance:
The presence of 2-Deoxy-2,2-difluoro-D-ribofuranose-3,5-dibenzoate-1-methanesulfonate as an impurity in Gemcitabine production necessitates its monitoring and control to ensure the safety and efficacy of the final drug product. As such, this compound is used in quality control processes to verify that the levels of impurities are within acceptable limits, adhering to regulatory guidelines and ensuring the overall quality of the anticancer agent.

Check Digit Verification of cas no

The CAS Registry Mumber 134877-42-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,8,7 and 7 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 134877-42:
(8*1)+(7*3)+(6*4)+(5*8)+(4*7)+(3*7)+(2*4)+(1*2)=152
152 % 10 = 2
So 134877-42-2 is a valid CAS Registry Number.
InChI:InChI=1/C22H24O8S/c1-22(2)18(29-20(24)16-12-8-5-9-13-16)17(28-21(22)30-31(3,25)26)14-27-19(23)15-10-6-4-7-11-15/h4-13,17-18,21H,14H2,1-3H3/t17-,18-,21-/m1/s1

134877-42-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name ((2R,3R,5S)-3-(Benzoyloxy)-4,4-difluoro-5-((methylsulfonyl)oxy)tetrahydrofuran-2-yl)methyl benzoate

1.2 Other means of identification

Product number -
Other names ((2R,3R,5S)-3-(Benzoyloxy)-4,4-difluoro-5-((methyl-sulfonyl)oxy)tetrahydrofuran-2-yl)methyl benzoate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:134877-42-2 SDS

134877-42-2Relevant articles and documents

Method for recovering mother liquor of gemcitabine intermediate

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Paragraph 0059-0060; 0069, (2021/06/22)

The invention provides a method for recovering mother liquor of a gemcitabine intermediate, and relates to the technical field of purification. The method for recovering the mother liquor of the gemcitabine intermediate provided by the invention comprises the following steps of: performing acidolysis of crystallization mother liquor containing a compound 5 and a compound 10 so as to obtain a mixture of a compound 3 and a compound 9; mixing the mixture of the compound 3 and the compound 9 with aniline, and performing dehydration reaction to obtain a mixture of Schiff base 12 and the compound 9; performing separation of the mixture of the Schiff base 12 and the compound 9 to obtain high-purity Schiff base 12; performing hydrolysis of the high-purity Schiff base 12 to obtain the compound 3; and mixing the compound 3 with methylsulfonyl chloride, and performing acylation reaction so as to obtain the high-purity compound 5. The method provided by the invention can remove the compound 10 in the crystallization mother liquor to obtain the high-purity compound 5, so that the yield and the purity of hydrochloride, namely gemcitabine hydrochloride, are improved.

Purification method of gemcitabine intermediate

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Paragraph 0079; 0083-0084, (2021/06/22)

The invention provides a purification method of a gemcitabine intermediate, and belongs to the technical field of drug intermediate synthesis. According to the invention, a compound 2 in an existing method (shown in a formula 1 and a formula 2 in a background art) is reduced to obtain a mixture containing a compound 3 and a byproduct compound 9; the mixture reacts with aniline; dehydration condensation reaction of the compound 3 and aniline is achieved; Schiff base is generated; the Schiff base and the byproduct compound 9 are easy to separate; a high-purity compound 3 can be obtained by performing simple acidic hydrolysis and separation on the separated Schiff base; the high-purity compound 3 is subjected to sulfonylation reaction to synthesize a gemcitabine hydrochloride key intermediate compound 5, so that the yield and the purity of the compound 5 can be improved, and the preparation yield and the product quality of the raw material medicine gemcitabine hydrochloride are ensured.

Industrial preparation process for key intermediate sulfonated saccharide of Gemcitabine

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Paragraph 0043; 0044; 0045, (2017/08/28)

The invention relates to a preparation method for a compound represented by a formula (I) shown in the description, i.e., a key intermediate sulfonated saccharide of Gemcitabine. The final product is prepared through subjecting a compound represented by a formula (II) shown in the description to sodium borohydride reduction, hydroxyl protection and resolution. The method is simple in process, high in yield and high in product purity and has no need of harsh reaction conditions, thereby being very suitable for industrial production.

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