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135042-12-5

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135042-12-5 Usage

Chemical Properties

White solid

Uses

N-Boc-cis-4-hydroxy-D-proline can be used:As a starting material in the synthesis of DNA mimicking pyrrolidine peptide nucleic acid (PNA) analog.In the synthesis of biologically important macrocyclic dilactones.As an intermediate in the synthesis of histamine H3?receptor antagonists.

Check Digit Verification of cas no

The CAS Registry Mumber 135042-12-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,5,0,4 and 2 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 135042-12:
(8*1)+(7*3)+(6*5)+(5*0)+(4*4)+(3*2)+(2*1)+(1*2)=85
85 % 10 = 5
So 135042-12-5 is a valid CAS Registry Number.
InChI:InChI=1/C10H17NO5/c1-10(2,3)16-9(15)11-5-6(12)4-7(11)8(13)14/h6-7,12H,4-5H2,1-3H3,(H,13,14)/t6-,7-/m1/s1

135042-12-5 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
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  • Alfa Aesar

  • (H26939)  N-Boc-cis-4-hydroxy-D-proline, 98%   

  • 135042-12-5

  • 250mg

  • 567.0CNY

  • Detail
  • Alfa Aesar

  • (H26939)  N-Boc-cis-4-hydroxy-D-proline, 98%   

  • 135042-12-5

  • 1g

  • 1578.0CNY

  • Detail
  • Aldrich

  • (706574)  N-Boc-cis-4-hydroxy-D-proline  97%

  • 135042-12-5

  • 706574-1G

  • 1,151.28CNY

  • Detail

135042-12-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Boc-Cis-4-Hydroxy-D-Proline

1.2 Other means of identification

Product number -
Other names N-Boc-cis-4-Hydroxy-D-proline

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:135042-12-5 SDS

135042-12-5Relevant articles and documents

Oxy-peptide nucleic acid with a pyrrolidine ring that is configurationally optimized for hybridization with DNA

Kitamatsu, Mizuki,Shigeyasu, Masanori,Okada, Tomoyuki,Sisido, Masahiko

, p. 1208 - 1209 (2004)

Four stereoisomers of oxy-peptide nucleic acids containing ether linkages in the main chain and conformationally-restricted pyrrolidine rings (pyrrolidine-based oxy-PNA = POPNA) were newly synthesized and investigated for binding to DNA. cis-L-POPNA with 9 adenine bases formed the most stable hybrid with dT9. The POPNA showed high sequence specificity similar to that of the Nielsen-type PNA and sharper melting behavior in hybridization with DNA than the Nielsen-type PNA.

HUMAN PLASMA KALLIKREIN INHIBITORS

-

Page/Page column 77-78, (2017/05/10)

Disclosed are compounds of formula I, and pharmaceutically acceptable salts thereof. The compounds are inhibitors of plasma kallikrein. Also provided are pharmaceutical compositions comprising at least one compound of the invention, and methods involving use of the compounds and compositions of the invention in the treatment and prevention of diseases and conditions characterized by unwanted plasma kallikrein activity.

Propargyloxyproline Regio- and Stereoisomers for Click-Conjugation of Peptides: Synthesis and Application in Linear and Cyclic Peptides

Northfield, Susan E.,Mountford, Simon J.,Wielens, Jerome,Liu, Mengjie,Zhang, Lei,Herzog, Herbert,Holliday, Nicholas D.,Scanlon, Martin J.,Parker, Michael W.,Chalmers, David K.,Thompson, Philip E.

, p. 1365 - 1372 (2015/09/15)

The use of the click reaction for the introduction of conjugate groups, such as affinity or fluorescent labels, to a peptide for the study of peptide biochemistry and pharmacology is widespread. However, the nature and location of substituted 1,2,3-triazoles in peptide sequences may markedly affect conformation or binding as compared with native sequences. We have examined the preparation and application of propargyloxyproline (Pop) residues as a precursor to such peptide conjugates. Pop residues are available in a range of regio- and stereoisomers from hydroxyproline precursors and are readily prepared in Fmoc-protected form. They can be incorporated routinely in peptide synthesis and broadly retain the conformational properties of the parent proline containing peptides. This is exemplified by the preparation of biotin- and fluorophore-labelled peptides derived from linear and cyclic peptides.

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